New Cholinesterase Inhibitor, Lipoic Acid-Nitrone Derivatives

Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2007, 28(2), , pp.225-228
Main Authors: Seo, Yun-Mi, Nam, Kang-Hee, Kang, Pill-Seong, Ko, Sung-Bo, Oh, Eu-Gene, Sung, Min-Tae, Choi, Byoung-Wook, Lee, Bong-Ho, Park, Jeong-Ho
Format: Article
Language:English
Subjects:
화학
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Summary:Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the antioxidant effect of LA-nitrone derivatives was not improved, they turned out to be effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in μM range.
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2007.28.2.225