Hydroxylated Hydrocinnamides as Hypocholesterolemic Agents

Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowerin...

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2007, 28(10), , pp.1787-1791
Main Authors: 이상구, Chul-Ho Lee, Eungsoo Kim, 정상헌, 이형규
Format: Article
Language:English
Subjects:
화학
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Summary:Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowering activities and the number of free phenolic hydroxy groups affect greatly the activities. 3,4-Dihydroxy hydrocinnamides obtained from amino acid derivatives containing a hydrophobic side chain such as alanine, valine, phenylalanine, and isoleucine exhibited potent cholesterol-lowering activities. KCI Citation Count: 9
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2007.28.10.1787