Anti-HIV-1 efficacy of extracts from medicinal plants

• Published in: The journal of microbiology 2010, 48(2), , pp.249-252
• Main Authors: Lee, S.A., The Catholic University of Korea, Seoul, Republic of Korea, Hong, S.K., The Catholic University of Korea, Seoul, Republic of Korea, Suh, C.I., The Catholic University of Korea, Seoul, Republic of Korea, Oh, M.H., The Catholic University of Korea, Seoul, Republic of Korea, Park, J.H., Hanbat National University, Daejeon, Republic of Korea, Choi, B.W., Hanbat National University, Daejeon, Republic of Korea, Park, S.W., The Catholic University of Korea, Seoul, Republic of Korea, Paik, S.Y., The Catholic University of Korea, Seoul, Republic of Korea
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; AIDS; Anti-HIV Agents - isolation & purification; Anti-HIV Agents - pharmacology; Anti-HIV Agents - toxicity; Anti-HIV-1; aqueous extracts; Biomedical and Life Sciences; Cell Line; Chloroform; DRUG PLANTS; folk medicine; Herbal medicine; HIV; HIV Core Protein p24 - analysis; HIV Reverse Transcriptase; HIV-1 - drug effects; Human immunodeficiency virus; Humans; Laboratories; Life Sciences; Medicinal plants; Microbiology; organic extracts; Plant extracts; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - toxicity; PLANTAS MEDICINALES; PLANTE MEDICINALE; Plants, Medicinal - chemistry; Virus Replication - drug effects; 생물학
• ISSN: 1225-8873; 1976-3794
• DOI: 10.1007/s12275-009-0176-9

The anti-HIV-1 activities of butanol, hexane, chloroform and water extracts from four widely used folk medicinal plants (Sophora flavescens, Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph) were evaluated in this study. The hexane extract of Pachyma hoelen Rumph, PH-4, showed effective inhibition against HIV-1. The 50% effective concentration (EC∧50) of PH-4 was 37.3 ㎍/ml in the p24 antigen assay and 36.8% in the HIV-1 recombinant RT activity test (at 200 ㎍/ml). In addition, the PH-4 showed the protective effect on the infected MT-4 cells, with a 58.2% rate of protection. The 50% cytotoxic concentration (CC∧50) of PH-4 was 100.6 ㎍/ml. These results suggest that PH-4 from Pachyma hoelen Rumph might be the candidate for the chemotherapy agent against HIV-1 infection with further study.