Biliary granular cell tumor

Granular cell tumor (GCT) is a benign neoplasm showing neuroectodermal differentiation and is most commonly found in the head and neck region, including the tongue.1 This tumor is now believed to occur in virtually any site of the body, including skin, breast, and gastrointestinal tract, with less t...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2015, 49(1), , pp.89-91
Main Authors: Jung, Changwon, Heo, Ilyeong, Kim, Sang Bum, Park, Sunhoo, Cho, Soo Youn
Format: Article
Language:English
Subjects:
Age
Bile
Brief Case Report
Females
Gallbladder
Medical imaging
Proteins
Tumors
병리학
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Summary:Granular cell tumor (GCT) is a benign neoplasm showing neuroectodermal differentiation and is most commonly found in the head and neck region, including the tongue.1 This tumor is now believed to occur in virtually any site of the body, including skin, breast, and gastrointestinal tract, with less than 1% developing in the biliary tract.2 To our knowledge, only one case of GCT of the biliary tract has been reported in Korea, which occurred in the gallbladder.3 Herein, we present another case of GCT of the biliary tract.DISCUSSION The first case of GCT was reported by Abrikossoffin 1926 in the skeletal muscle of the tongue.4 Since then, there have been some discrepancies regarding the origin of GCT based on histologic and immunohistochemical findings, including myogenic, histiogenic, neurogenic, and multicentric histogeneses.5 The exact histogenesis is still unclear, but a neural origin, more specifically Schwannian type neuroectodermal origin, is favored by many authors1,5,6 because the tumor cells show positivity for S100 protein, which is normally found in the central nervous system and peripherally in Schwann cells.6,7 GCT has a distinct histological appearance, being composed of polygonal eosinophilic cells that contain cytoplasmic granules strongly reactive to PAS.In summary, biliary GCT can cause symptoms related to biliary obstruction and might present with a clinical impression of cholangiocarcinoma.[...]GCT should be included in the differential diagnosis of biliary tract tumors, even though the incidence is extremely low.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2014.10.07