MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis

While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinicopathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC). The present study investigated the correlation between MUC2 expression and clinicopathological parameters in 167 human GC...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2015, 49(3), , pp.249-256
Main Authors: Pyo, Jung-Soo, Sohn, Jin Hee, Kang, Guhyun, Kim, Dong-Hoon, Kim, Kyungeun, Do, In-Gu, Kim, Dong Hyun
Format: Article
Language:English
Subjects:
Antigens
Cancer
Clinicopathological significance
Gastric carcinoma
Lymphatic system
Meta-analysis
Metastasis
MUC2
Original
Peptides
Studies
병리학
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Summary:While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinicopathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC). The present study investigated the correlation between MUC2 expression and clinicopathological parameters in 167 human GCs. In addition, to confirm the clinicopathological significance of MUC2 expression, we performed a systematic review and meta-analysis in 1,832 GCs. MUC2 expression was found in 58 of 167 GCs (34.7%). MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively). However, MUC2 expression was not correlated with Lauren's classification and tumor differentiation. In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren's classification, pN stage, or pTNM stage. MUC2 expression was correlated with a lower tumor depth and lower lymph node metastasis in our study; the meta-analysis showed a correlation of MUC2 expression with tumor differentiation and lower tumor depth.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2015.03.27