Sebaceous carcinoma arising in mature cystic teratoma of ovary

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2013, 47(4), , pp.383-387
Main Authors: An, Hyo Jeong, Jung, Yong Han, Yoon, Hye Kyoung, Jung, Soo Jin
Format: Article
Language:English
Subjects:
Abdomen
Case Study
Cysts
Hypotheses
Melanoma
Molecular weight
Palliative care
Sepsis
Skin
Transplants & implants
Tumors
병리학
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Summary:Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.
ISSN:1738-1843
2383-7837
2092-8920
2383-7845
DOI:10.4132/KoreanJPathol.2013.47.4.383