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Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing
Background The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is b...
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| Published in: | Archives of plastic surgery 2014, 41(6), , pp.638-646 |
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| container_end_page | 646 |
| container_issue | 6 |
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| container_title | Archives of plastic surgery |
| container_volume | 41 |
| creator | Cai, Elijah Zhengyang Teo, Erin Yiling Jing, Lim Koh, Yun Pei Qian, Tan Si Wen, Feng Lee, James Wai Kit Hing, Eileen Chor Hoong Yap, Yan Lin Lee, Hanjing Lee, Chuen Neng Teoh, Swee-Hin Lim, Jane Lim, Thiam Chye |
| description | Background
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
Methods
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
Results
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm
2
, 4.90 cm
2
, 3.12 cm
2
, 1.84 cm
2
; Mepitel (n=6): 10.29 cm
2
, 5.53 cm
2
, 3.63 cm
2
, 2.02 cm
2
; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
Conclusions
BPM is comparable to Mepitel as a safe and efficacious wound dressing. |
| doi_str_mv | 10.5999/aps.2014.41.6.638 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_830890</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_21b814e3d4d5452bbd3d932e76741d30</doaj_id><sourcerecordid>1625348070</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-85c137a07ebbf4d0d6bc34624a628033f00666668fadbec831f144623f60be2a3</originalsourceid><addsrcrecordid>eNp9UU1v1DAQjRCIVqU_gAvKkUuCv-I4HJCWBcpK5UOoiKPlj8nW2yTe2kml_vs6G1johbmM5Xnz3tO8LHuJUVk1TfNG7WNJEGYlwyUvORVPslNCKCs4rvHT45vTk-w8xh1KxVHFK_w8OyEVbRKMnWar984Xaz_spq0awebffXdv1D74TpnRD5B_gV4HNUB8m6_yr_4OuvyXnwabfwgQoxu2L7JnreoinP_uZ9nPTx-v1p-Ly28Xm_XqsjBJbCxEZTCtFapB65ZZZLk2lHHCFCcCUdome3OJVlkNRlDcYpbmtOVIA1H0LHu98A6hlTfGSa_coW-9vAly9eNqIwVFokEJulmg1qud3AfXq3B_wB8-fNhKFUZnOpAEa4EZUMtsxSqitaW2oQRqXjNs6cz1buHaT7oHa2AYg-oekT6eDO46WbqTjBBBEPvrOx31doI4yt5FA12XjuqnKDFPaTCB6lkLL1ATfIwB2qMMRnIOXabQ5Ry6ZFhymUJPO6_-9Xfc-BNxAqAFMF476EHu_BSGFNR_OB8ApLa2Yg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1625348070</pqid></control><display><type>article</type><title>Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing</title><source>Open Access: PubMed Central</source><creator>Cai, Elijah Zhengyang ; Teo, Erin Yiling ; Jing, Lim ; Koh, Yun Pei ; Qian, Tan Si ; Wen, Feng ; Lee, James Wai Kit ; Hing, Eileen Chor Hoong ; Yap, Yan Lin ; Lee, Hanjing ; Lee, Chuen Neng ; Teoh, Swee-Hin ; Lim, Jane ; Lim, Thiam Chye</creator><creatorcontrib>Cai, Elijah Zhengyang ; Teo, Erin Yiling ; Jing, Lim ; Koh, Yun Pei ; Qian, Tan Si ; Wen, Feng ; Lee, James Wai Kit ; Hing, Eileen Chor Hoong ; Yap, Yan Lin ; Lee, Hanjing ; Lee, Chuen Neng ; Teoh, Swee-Hin ; Lim, Jane ; Lim, Thiam Chye</creatorcontrib><description>Background
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
Methods
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
Results
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm
2
, 4.90 cm
2
, 3.12 cm
2
, 1.84 cm
2
; Mepitel (n=6): 10.29 cm
2
, 5.53 cm
2
, 3.63 cm
2
, 2.02 cm
2
; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
Conclusions
BPM is comparable to Mepitel as a safe and efficacious wound dressing.</description><identifier>ISSN: 2234-6163</identifier><identifier>EISSN: 2234-6171</identifier><identifier>DOI: 10.5999/aps.2014.41.6.638</identifier><identifier>PMID: 25396174</identifier><language>eng</language><publisher>333 Seventh Avenue, 18th Floor, New York, NY 10001, USA: Thieme Medical Publishers, Inc</publisher><subject>hyaluronic acid ; Original ; Original Article ; polycaprolactone ; rabbit ; skin ; wounds ; 성형외과학</subject><ispartof>Archives of Plastic Surgery, 2014, 41(6), , pp.638-646</ispartof><rights>The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)</rights><rights>Copyright © 2014 The Korean Society of Plastic and Reconstructive Surgeons 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-85c137a07ebbf4d0d6bc34624a628033f00666668fadbec831f144623f60be2a3</citedby><cites>FETCH-LOGICAL-c539t-85c137a07ebbf4d0d6bc34624a628033f00666668fadbec831f144623f60be2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228204/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228204/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25396174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001928196$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Elijah Zhengyang</creatorcontrib><creatorcontrib>Teo, Erin Yiling</creatorcontrib><creatorcontrib>Jing, Lim</creatorcontrib><creatorcontrib>Koh, Yun Pei</creatorcontrib><creatorcontrib>Qian, Tan Si</creatorcontrib><creatorcontrib>Wen, Feng</creatorcontrib><creatorcontrib>Lee, James Wai Kit</creatorcontrib><creatorcontrib>Hing, Eileen Chor Hoong</creatorcontrib><creatorcontrib>Yap, Yan Lin</creatorcontrib><creatorcontrib>Lee, Hanjing</creatorcontrib><creatorcontrib>Lee, Chuen Neng</creatorcontrib><creatorcontrib>Teoh, Swee-Hin</creatorcontrib><creatorcontrib>Lim, Jane</creatorcontrib><creatorcontrib>Lim, Thiam Chye</creatorcontrib><title>Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing</title><title>Archives of plastic surgery</title><addtitle>Arch Plast Surg</addtitle><description>Background
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
Methods
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
Results
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm
2
, 4.90 cm
2
, 3.12 cm
2
, 1.84 cm
2
; Mepitel (n=6): 10.29 cm
2
, 5.53 cm
2
, 3.63 cm
2
, 2.02 cm
2
; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
Conclusions
BPM is comparable to Mepitel as a safe and efficacious wound dressing.</description><subject>hyaluronic acid</subject><subject>Original</subject><subject>Original Article</subject><subject>polycaprolactone</subject><subject>rabbit</subject><subject>skin</subject><subject>wounds</subject><subject>성형외과학</subject><issn>2234-6163</issn><issn>2234-6171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>DOA</sourceid><recordid>eNp9UU1v1DAQjRCIVqU_gAvKkUuCv-I4HJCWBcpK5UOoiKPlj8nW2yTe2kml_vs6G1johbmM5Xnz3tO8LHuJUVk1TfNG7WNJEGYlwyUvORVPslNCKCs4rvHT45vTk-w8xh1KxVHFK_w8OyEVbRKMnWar984Xaz_spq0awebffXdv1D74TpnRD5B_gV4HNUB8m6_yr_4OuvyXnwabfwgQoxu2L7JnreoinP_uZ9nPTx-v1p-Ly28Xm_XqsjBJbCxEZTCtFapB65ZZZLk2lHHCFCcCUdome3OJVlkNRlDcYpbmtOVIA1H0LHu98A6hlTfGSa_coW-9vAly9eNqIwVFokEJulmg1qud3AfXq3B_wB8-fNhKFUZnOpAEa4EZUMtsxSqitaW2oQRqXjNs6cz1buHaT7oHa2AYg-oekT6eDO46WbqTjBBBEPvrOx31doI4yt5FA12XjuqnKDFPaTCB6lkLL1ATfIwB2qMMRnIOXabQ5Ry6ZFhymUJPO6_-9Xfc-BNxAqAFMF476EHu_BSGFNR_OB8ApLa2Yg</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Cai, Elijah Zhengyang</creator><creator>Teo, Erin Yiling</creator><creator>Jing, Lim</creator><creator>Koh, Yun Pei</creator><creator>Qian, Tan Si</creator><creator>Wen, Feng</creator><creator>Lee, James Wai Kit</creator><creator>Hing, Eileen Chor Hoong</creator><creator>Yap, Yan Lin</creator><creator>Lee, Hanjing</creator><creator>Lee, Chuen Neng</creator><creator>Teoh, Swee-Hin</creator><creator>Lim, Jane</creator><creator>Lim, Thiam Chye</creator><general>Thieme Medical Publishers, Inc</general><general>The Korean Society of Plastic and Reconstructive Surgeons</general><general>대한성형외과학회</general><scope>0U6</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope></search><sort><creationdate>201411</creationdate><title>Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing</title><author>Cai, Elijah Zhengyang ; Teo, Erin Yiling ; Jing, Lim ; Koh, Yun Pei ; Qian, Tan Si ; Wen, Feng ; Lee, James Wai Kit ; Hing, Eileen Chor Hoong ; Yap, Yan Lin ; Lee, Hanjing ; Lee, Chuen Neng ; Teoh, Swee-Hin ; Lim, Jane ; Lim, Thiam Chye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-85c137a07ebbf4d0d6bc34624a628033f00666668fadbec831f144623f60be2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>hyaluronic acid</topic><topic>Original</topic><topic>Original Article</topic><topic>polycaprolactone</topic><topic>rabbit</topic><topic>skin</topic><topic>wounds</topic><topic>성형외과학</topic><toplevel>online_resources</toplevel><creatorcontrib>Cai, Elijah Zhengyang</creatorcontrib><creatorcontrib>Teo, Erin Yiling</creatorcontrib><creatorcontrib>Jing, Lim</creatorcontrib><creatorcontrib>Koh, Yun Pei</creatorcontrib><creatorcontrib>Qian, Tan Si</creatorcontrib><creatorcontrib>Wen, Feng</creatorcontrib><creatorcontrib>Lee, James Wai Kit</creatorcontrib><creatorcontrib>Hing, Eileen Chor Hoong</creatorcontrib><creatorcontrib>Yap, Yan Lin</creatorcontrib><creatorcontrib>Lee, Hanjing</creatorcontrib><creatorcontrib>Lee, Chuen Neng</creatorcontrib><creatorcontrib>Teoh, Swee-Hin</creatorcontrib><creatorcontrib>Lim, Jane</creatorcontrib><creatorcontrib>Lim, Thiam Chye</creatorcontrib><collection>Thieme Journals (Open Access)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index (Open Access)</collection><jtitle>Archives of plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Elijah Zhengyang</au><au>Teo, Erin Yiling</au><au>Jing, Lim</au><au>Koh, Yun Pei</au><au>Qian, Tan Si</au><au>Wen, Feng</au><au>Lee, James Wai Kit</au><au>Hing, Eileen Chor Hoong</au><au>Yap, Yan Lin</au><au>Lee, Hanjing</au><au>Lee, Chuen Neng</au><au>Teoh, Swee-Hin</au><au>Lim, Jane</au><au>Lim, Thiam Chye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing</atitle><jtitle>Archives of plastic surgery</jtitle><addtitle>Arch Plast Surg</addtitle><date>2014-11</date><risdate>2014</risdate><volume>41</volume><issue>6</issue><spage>638</spage><epage>646</epage><pages>638-646</pages><issn>2234-6163</issn><eissn>2234-6171</eissn><abstract>Background
The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing.
Methods
16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration.
Results
Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm
2
, 4.90 cm
2
, 3.12 cm
2
, 1.84 cm
2
; Mepitel (n=6): 10.29 cm
2
, 5.53 cm
2
, 3.63 cm
2
, 2.02 cm
2
; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups.
Conclusions
BPM is comparable to Mepitel as a safe and efficacious wound dressing.</abstract><cop>333 Seventh Avenue, 18th Floor, New York, NY 10001, USA</cop><pub>Thieme Medical Publishers, Inc</pub><pmid>25396174</pmid><doi>10.5999/aps.2014.41.6.638</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of Plastic Surgery, 2014, 41(6), , pp.638-646 |
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| language | eng |
| recordid | cdi_nrf_kci_oai_kci_go_kr_ARTI_830890 |
| source | Open Access: PubMed Central |
| subjects | hyaluronic acid Original Original Article polycaprolactone rabbit skin wounds 성형외과학 |
| title | Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing |
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