Antibacterial and cytotoxic activities of Schiff base analogues of 4-aminoantipyrine

Schiff base is the class of compounds showing wide range of biological activities having the azomethine (-N=CH-) active pharmacophore, which play major roles in their significant bio-activities. A series of Schiff base analogues of 4-aminoantipyrine analogues have been tested for bactericidal and cy...

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Bibliographic Details
Published in:Applied biological chemistry 2014, 57(5), , pp.613-619
Main Authors: Alam, Mohammad Sayed, Lee, Dong-Ung, Bari, Md. Latiful
Format: Article
Language:English
Subjects:
Applied Microbiology
Artemia
Bioassays
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Cytotoxicity
E coli
Imines
Qualitative analysis
Saline water
Toxicity
농학
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Summary:Schiff base is the class of compounds showing wide range of biological activities having the azomethine (-N=CH-) active pharmacophore, which play major roles in their significant bio-activities. A series of Schiff base analogues of 4-aminoantipyrine analogues have been tested for bactericidal and cytotoxic activities against selected bacterial strains and brine shrimp ( Artemia salina ) nauplii, respectively. Of the compounds tested, two compounds showed a good inhibition of bacterial growth against E. coli and C. sakazakii , whereas three compounds demonstrated high cytotoxicity with LC 50 values of 225, 480, and 581 ppm, in a short term bioassay using A. salina . Qualitative structure-cytotoxic activity relationships were studied using physicochemical parameters; a good correlation between clogP and cytotoxic activity was observed.
ISSN:1738-2203
2468-0834
2234-344X
2468-0842
DOI:10.1007/s13765-014-4201-2