The potential restorative effects of strontium-doped bioactive glass on bone microarchitecture after estrogen-deficieny induced osteoporosis: Physicochemical and histomorphometric analyses

• Published in: Applied biological chemistry 2013, 56(5), , pp.533-540
• Main Authors: Jebahi Samira, Oudadesse Hassane, Jiheun, Elleuch, Tounsi Slim, Hassib, Keskes, pellen Pascal, Rebai Tarek, El Feki Abdelfatteh, El Feki Hafed
• Format: Article
• Language: English
• Subjects: Bioceramics; Bioglass; Biological activity; Biomaterials; Biomedical materials; Bone histomorphometry; Bone implants; Bone remodeling; Calcium; Calcium phosphates; Computer architecture; Estrogens; Fourier analysis; Fourier transforms; Implantation; Infrared spectroscopy; Osteoporosis; Ovariectomy; Scanning electron microscopy; Strontium; Strontium compounds; Surgical implants; X-ray diffraction; 농학
• ISSN: 2468-0834; 2468-0842
• DOI: 10.1007/s13765-013-3167-9

Strontium (Sr) compounds have become increasingly popular in the field of osteoporosis treatment. However, the quality of new bone after implantation of strontium-containing bioceramics has yet to be investigated. In the present study, the newly formed bone tissue around strontium-doped bioactive glass (BG-Sr) implants was characterized. BG-Sr was implanted in the femoral condyl of ovariectomised rats (OVX). The resected bone was prepared for analysis using several physico-chemical and biological assays such as Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, and histomorphometry. BG-Sr biomaterial favored calcium phosphate layer integration on the surface of the glass and offered better bioactivity. Moreover, the histomorphometric analysis demonstrated that BV/TV, N. Ob were significantly higher in BG-Sr treated rats groups than those of BG groups. However, Ob. S/BS, and OV/BV were significantly lower in BG-Sr treated rats groups than those of BG groups. The (Oc.S/BS) was significantly decreased in BG-Sr groups, when compared with that of BG rat groups. On the other hand, the MS/BS had not significantly decreased in the BG-Sr treated rats groups when compared with that of BG groups, however; it was significantly higher when compared with control and OVX groups. These findings suggest that BG-Sr can be used as an inhibitory therapeutic potential of osteoporosis by delivering strontium to stimulate new bone remodeling.