Anti-bacterial and Anti-viral Activities of Extracts from Terminalia chebula Barks

• Published in: Applied biological chemistry 2011, 54(2), , pp.295-298
• Main Authors: Lee, D.S., Jeju National University, Jeju, Republic of Korea, Boo, K.H., Jeju National University, Jeju, Republic of Korea, Woo, J.K., Jeju National University, Jeju, Republic of Korea, Duan, Fangmeng, Jeju National University, Jeju, Republic of Korea, Lee, K.H., Jeju National University School of Medicine, Jeju, Republic of Korea, Kwon, T.K., Keimyung University, Daegu, Republic of Korea, Lee, H.Y., Jeju National University, Jeju, Republic of Korea, Riu, Key Zung, Jeju National University, Jeju, Republic of Korea
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Antiviral agents; Applied Microbiology; Biological Techniques; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; GLICOPROTEINAS; GLYCOPROTEINE; GLYCOPROTEINS; Glycosylation; Methanol; oxygen radical; Short Communication; Superoxide; Terminalia chebula; trafficking inhibitor; Viruses; 농학
• ISSN: 1738-2203; 2468-0834; 2234-344X; 2468-0842
• DOI: 10.3839/jksabc.2011.046

Effects of methanol extract of Terminalia chebula on antibacterial activity and the generation of superoxide radical in Bacillus subtilis, as well as on syncytium formation and cytopathic activity in virus-infected baby hamster kidney cells were examined. The extract effectively inhibited syncytium formation in a concentration-dependent manner, and infectious virus production was markedly reduced. However, glycoprotein synthesis was not affected. These results collectively indicate that methanol extract of T. chebula potentially inhibit glycosylation by acting as a suppressor of intracellular glycosylation trafficking.