Inhibitory effects of dicaffeoylquinic acids from Artemisia dubia on aldo-keto reductase family 1b10

The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified...

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Bibliographic Details
Published in:Applied biological chemistry 2010, 53(6), , pp.826-830
Main Authors: Ju, Lee Hee, Young, Lee Joo, Kim Sang Min, Nho Chu Won, Jung, Sang Hoon, Song Dae-Geun, Young, Kim Chul, Cheol-Ho, Pan
Format: Article
Language:English
Subjects:
Acetic acid
Aldo-keto reductase
Artemisia dubia
Derivatives
Dihydroxybenzoic acid
Ethyl acetate
Glucose
Purification
Quercetin
Reductases
농학
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Summary:The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dihydroxybenzoic acid (1), quercetin 3-O-β-glucose (2), 3,4-DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of IC50 1.24-2.29 μM, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-β-glucose showed no inhibitory activity on rhAKR1B10.
ISSN:2468-0834
2468-0842
DOI:10.3839/jksabc.2010.125