Antibacterial and Synergistic Activity of Prenylated Chalcone Isolated from the Roots of Sophora flavescens

7,9,2',4'-Tetrahydroxy-8-isopentenyl-5-methoxychalcone (THIPMC), isolated from the roots of Sophora flavescens Ait., was found to be active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), either alone or in combination with ampicillin...

Full description

Saved in:
Bibliographic Details
Published in:Applied biological chemistry 2010, 53(3), , pp.290-296
Main Authors: Lee, G.S., Pusan National University, Yangsan, Republic of Korea, Kim, E.S., Wonkwang Health Science College, Iksan, Republic of Korea, Cho, S.I., Pusan National University, Yangsan, Republic of Korea, Kim, J.H., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea, Choi, G.Y., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea, Ju, Y.S., Woosuk University, Samrye, Republic of Korea, Park, S.H., Wonkwang University, Iksan, Republic of Korea, Jeong, S.I., Woosuk University, Samrye, Republic of Korea, Kim, H.J., Woosuk University, Samrye, Republic of Korea
Format: Article
Language:English
Subjects:
Ampicillin
Antibiotic resistance
Antibiotics
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Drug resistance
enterotoxin gene
ENTEROTOXINAS
ENTEROTOXINE
ENTEROTOXINS
Gentamicin
Infections
Methicillin
MRSA
Roots
Sophora flavescens
Staphylococcus aureus
Staphylococcus infections
Synergistic effect
THIPMC
Vancomycin
VRE
농학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:7,9,2',4'-Tetrahydroxy-8-isopentenyl-5-methoxychalcone (THIPMC), isolated from the roots of Sophora flavescens Ait., was found to be active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), either alone or in combination with ampicillin (AM) or gentamicin (GM), vis checkerboard assay. Minimum inhibitory concentrations ranged from to 8 ㎍/mL for THIPMC, from 128 to 1024 ㎍/mL for AM, and from 128 to 512 ㎍/mL for GM, respectively. The combinations of THIPMC plus AM or GM yielded a fractional inhibitory concentration index ranging from 0.188 to 0.375 ㎍/mL, thereby indicating a synergistic effect. These findings suggest that THIPMC alone or in combination with antibiotics against MRSA might be useful for controlling MRSA infections. However, VRE infection was only effectively treated by THIPMC alone.
ISSN:1738-2203
2468-0834
2234-344X
2468-0842
DOI:10.3839/jksabc.2010.045