Inhibitory effects of an ethanol extract of Artemisia capillaris on inflammatory mediators from LPS-stimulated RAW 264.7 cells

Artemisia capillaris is a perennial herb that belongs to the family Campositae spp, and has been utilized in Korea for the treatment of abdominal pain, hepatitis, chronic liver disease, and coughing. The anti-inflammatory activity of the ethanol extract of A. capillaris (EtEAC) was investigated in t...

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Bibliographic Details
Published in:Applied biological chemistry 2010, 53(3), , pp.275-282
Main Authors: Lim Hee-Kyoung, Cho, Somi K, Park Sanggyu, Cho Moonjae
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Catechin
Cyclooxygenase-2
Cytokines
Ethanol
Gene expression
Hepatitis
Inflammation
Interleukin 1
Interleukin 6
Lipopolysaccharides
Liver diseases
Medical treatment
Nitric oxide
Nitric-oxide synthase
Pain
Scavenging
Transcription
농학
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Summary:Artemisia capillaris is a perennial herb that belongs to the family Campositae spp, and has been utilized in Korea for the treatment of abdominal pain, hepatitis, chronic liver disease, and coughing. The anti-inflammatory activity of the ethanol extract of A. capillaris (EtEAC) was investigated in this study. EtEAC did not affect the viability of various cells in a concentration range of 0-200 μg/mL. The DPPH radical scavenging ability of 10 μg/mL of EtEAC was comparable to that of 10 μg/mL of catechin. EtEAC exerted an anti-inflammatory effect on the mRNA expression levels of typical inflammatory cytokines (IL-6, IL1β) and cyclooxygenase-2 in LPS-stimulated RAW 264.7 cells. Additionally, EtEAC reduced nitric oxide (NO) production via the downregulation of inducible nitric oxide synthase transcription, rather than by scavenging NO. EtEAC exerted its anti-inflammatory effects by suppressing the activation of p38 and ERK at 200 μg/mL in LPS-stimulated RAW 264.7 cells.
ISSN:2468-0834
2468-0842
DOI:10.3839/jksabc.2010.043