DNA Repair of Eukaryotes Associated with Non-coding Small RNAs

In eukaryotes, most of the genome are transcribed,however only a small proportion of total transcripts encodes for protein, thus resulting in many of noncoding RNAs. In order to recover DNA damage including DNA double-strand breaks (DSBs) eukaryotes have evolved complex mechanisms and these are proc...

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Bibliographic Details
Published in:Journal of applied biological chemistry 2013, 56(1), , pp.37-42
Main Authors: Kang, Han-Chul, Yoon, Sang-Hong, Lee, Chang-Muk, Roh, Kyung Hee
Format: Article
Language:English
Subjects:
농학
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Summary:In eukaryotes, most of the genome are transcribed,however only a small proportion of total transcripts encodes for protein, thus resulting in many of noncoding RNAs. In order to recover DNA damage including DNA double-strand breaks (DSBs) eukaryotes have evolved complex mechanisms and these are processed through coordinated mechanisms of protein sensors,transducers, and effectors including RNAs. During recent years,small RNAs have been increasingly studied and gradually considered as key regulators in various aspects of biology. Upon DNA damage, small RNAs including diRNAs (DSB induced RNA) are generated in both plant and human cell lines. Inhibition of their biogenesis has severe influence on DSB repair system. KCI Citation Count: 0
ISSN:1976-0442
2234-7941
DOI:10.3839/jabc.2013.007