Enantiomeric Compounds with Antileishimanial Activitiesfrom a Sponge, Plakortis sp

As part of a program to discover bioactive natural products from marine organisms, two new enantiomers, ent-3,6-Epidioxy-4,6,8,10-tetraethyltetradeca-7,11-dienoic acid and ent-[3,5-Diethyl-5-(2-ethyl-hex-3-enyl)- 5H-furan-2-ylidene]-acetic acid methyl ether, were isolated from a sponge Plakortis sp....

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied biological chemistry 2006, 49(1), , pp.21-23
Main Authors: Chi Won Lim, Yeon-Kye Kim, Ho Dong Youn, Hee-Yeon Park
Format: Article
Language:Korean
Subjects:
농학
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As part of a program to discover bioactive natural products from marine organisms, two new enantiomers, ent-3,6-Epidioxy-4,6,8,10-tetraethyltetradeca-7,11-dienoic acid and ent-[3,5-Diethyl-5-(2-ethyl-hex-3-enyl)- 5H-furan-2-ylidene]-acetic acid methyl ether, were isolated from a sponge Plakortis sp. These compounds showed strong in vitro antiproliferative effects on promastigotes of Leishmania mexicania, flagellate protozoan that causes leishmaniasis. Structures were assumed by interpretation of NMR spectroscopic data and optical rotation. Both compounds exhibited significant antileishmanial activities in vitro with IC50 of 1.0-23.0 μg/ml. KCI Citation Count: 0
ISSN:1976-0442
2234-7941