Biological Activities of Fractions from Methanolic Extract of Picrasma quassioides

Antioxidant, antidiabetes, and anticancer activities of fractions (water, hexane, EtOAc, and BuOH) from methanolic (MeOH) extract of Picrasma quassioides were evaluated in vitro. Among the four fractions, BuOH fraction showed cytotoxic activity on the human stomach carcinoma cells (NCI-N87) without...

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Bibliographic Details
Published in:Journal of plant biology = Singmul Hakhoe chi 2009, 52(4), , pp.325-331
Main Authors: Yin, Yu, Kangwon National University, Chuncheon, Republic of Korea, Heo, S.I., Kangwon National University, Chuncheon, Republic of Korea, Roh, K.S., Keimyung University, Daegu, Republic of Korea, Wang, M.H., Kangwon National University, Chuncheon, Republic of Korea
Format: Article
Language:English
Subjects:
Anticancer
Anticancer properties
Antidiabetes
ANTIOXIDANTES
ANTIOXIDANTS
ANTIOXYDANT
Apoptosis
Biomedical and Life Sciences
Cancer
Carbohydrates
Cell death
Cytotoxicity
Diabetes
Enzymes
Flow cytometry
Fractions
Gastric cancer
Gene expression
Glucose
Hexanes
Hyperglycemia
Life Sciences
MeOH extract
Original Research
Penicillin
Picrasma quassioides
Plant Breeding/Biotechnology
Plant Ecology
Plant Genetics and Genomics
Plant Sciences
Plant Systematics/Taxonomy/Biogeography
생물학
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Summary:Antioxidant, antidiabetes, and anticancer activities of fractions (water, hexane, EtOAc, and BuOH) from methanolic (MeOH) extract of Picrasma quassioides were evaluated in vitro. Among the four fractions, BuOH fraction showed cytotoxic activity on the human stomach carcinoma cells (NCI-N87) without cytotoxic effect on the human normal kidney cells (293) by MTT assay. Considering these results, we adapted BuOH fraction of MeOH extract to the assessment of apoptosis by flow cytometry and mRNA expression levels of established apoptotic-related genes on NCI-N87 cells. The experiments showed that BuOH fraction could induce apoptosis on NCI-N87 cells significantly. Take together these results, P. quassioides showed that it could be used for potential pharmaceutical products.
ISSN:1226-9239
1867-0725
DOI:10.1007/s12374-009-9042-x