The development of nano-polyplex efficacious against osteoarthropathy

This study is a manufacturing design to reduce side effects and to increase use rate of organism by inclusion of Alendronate, a kind of bisphosphonate used for treatment and prevention of osteoporosis, into the center of W1/O/W2 multi-emulsions. We have used enteric coating materials insolvent in ac...

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Bibliographic Details
Published in:Journal of industrial and engineering chemistry (Seoul, Korea) 2014, 20(4), , pp.2490-2496
Main Authors: Son, Jae-Min, Park, Young-Ho, Lee, Chang-Seop
Format: Article
Language:English
Subjects:
Adhesion
Alendronate
Encapsulation
Inclusions
Membranes
Mucous membrane
Nanostructure
Optimization
PEO polymer
Phases
Polyvinyl alcohols
화학공학
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Summary:This study is a manufacturing design to reduce side effects and to increase use rate of organism by inclusion of Alendronate, a kind of bisphosphonate used for treatment and prevention of osteoporosis, into the center of W1/O/W2 multi-emulsions. We have used enteric coating materials insolvent in acid by adding adhesion property of mucous membrane. We have secured enteric nature with Eudragit by using PEO (polyethylene oxide) polymer as adhesion property of mucous membrane and have encapsulated using PVA (polyvinyl alcohol). We have conducted optimum test per phases and it was found out that the best result was achieved when we have used an ideal quantity ratio of Alendronate and PEO in 1:0.1. The quantity of PEO molecule was 300,000 and oily phase was manufactured with the addition of water phase, and L100 Type Eudragit was used for the manufacturing. We have manufactured the optimum multiple-emulsions by adding 1% PVA to this. Multi-emulsions manufactured in this study had a 70% efficiency of encapsulation rate and grain ratio was 800nm and have shown enteric stability and efficiency.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2013.10.031