Ovarian cancer biomarker discovery based on genomic approaches

Ovarian cancer presents at an advanced stage in more than 75% of patients. Early detection has great promise to improve clinical outcomes. Although the advancing proteomic technologies led to the discovery of numerous ovarian cancer biomarkers, no screening method has been recommended for early dete...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer prevention 2013, 18(4), , pp.298-312
Main Authors: Lee, Jung-Yun, Kim, Hee Seung, Suh, Dong Hoon, Kim, Mi-Kyung, Chung, Hyun Hoon, Song, Yong-Sang
Format: Article
Language:English
Subjects:
Review
예방의학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ovarian cancer presents at an advanced stage in more than 75% of patients. Early detection has great promise to improve clinical outcomes. Although the advancing proteomic technologies led to the discovery of numerous ovarian cancer biomarkers, no screening method has been recommended for early detection of ovarian cancer. Complexity and heterogeneity of ovarian carcinogenesis is a major obstacle to discover biomarkers. As cancer arises due to accumulation of genetic change, understanding the close connection between genetic changes and ovarian carcinogenesis would provide the opportunity to find novel gene-level ovarian cancer biomarkers. In this review, we summarize the various gene-based biomarkers by genomic technologies, including inherited gene mutations, epigenetic changes, and differential gene expression. In addition, we suggest the strategy to discover novel gene-based biomarkers with recently introduced next generation sequencing.
ISSN:2288-3649
2288-3657
DOI:10.15430/JCP.2013.18.4.298