Analysis of PAX8 immunohistochemistry in lung cancers: a meta-analysis

Background: In this meta-analysis, we aimed to evaluate the PAX8 immunohistochemical expressions in primary lung cancers and metastatic cancers to the lung. Methods: We identified and reviewed relevant articles from the PubMed databases. Ultimately, 18 articles were included in this meta-analysis. P...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pathology and translational medicine 2020, 54(4), , pp.300-309
Main Authors: Jeong, Jae Han, Kim, Nae Yu, Pyo, Jung-Soo
Format: Article
Language:English
Subjects:
Arsenic
Bias
Confidence intervals
immunohistochemistry
Kidneys
lung
Lung cancer
Meta-analysis
Metastasis
metastatic
Original
pax8
primary
Studies
Thyroid gland
Transcription factors
Tumors
Urogenital system
병리학
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: In this meta-analysis, we aimed to evaluate the PAX8 immunohistochemical expressions in primary lung cancers and metastatic cancers to the lung. Methods: We identified and reviewed relevant articles from the PubMed databases. Ultimately, 18 articles were included in this meta-analysis. PAX8 expression rates were analyzed and compared between primary and metastatic lung cancers. Results: The PAX8 expression rate in primary lung cancers was 0.042 (95% confidence interval [CI], 0.025 to 0.071). PAX8 expression rates of small cell (0.129; 95% CI, 0.022 to 0.496) and non-small cell carcinomas of the lung (0.037; 95% CI, 0.022 to 0.061) were significantly different (p = .049 in a meta-regression test). However, the PAX8 expression rates of adenocarcinoma (0.013; 95% CI, 0.006 to 0.031) and squamous cell carcinoma (0.040; 95% CI, 0.016 to 0.097) were not significantly different. PAX8 expression rates of metastatic carcinomas to the lung varied, ranging from 1.8% to 94.9%. Metastatic carcinomas from the lung to other organs had a PAX8 expression rate of 6.3%. The PAX8 expression rates of metastatic carcinomas from the female genital organs, kidneys, and thyroid gland to the lung were higher than those of other metastatic carcinomas. Conclusions: Primary lung cancers had a low PAX8 expression rate regardless of tumor subtype. However, the PAX8 expression rates of metastatic carcinomas from the female genital organs, kidneys, and thyroid were significantly higher than those of primary lung cancers.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2020.06.08