The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

• Published in: Clinical hypertension 2019, 25(4), , pp.31-38
• Main Authors: Kim, Hack-Lyoung, Lim, Woo-Hyun, Seo, Jae-Bin, Kim, Sang-Hyun, Zo, Zoo-Hee, Kim, Myung-A
• Format: Article
• Language: English
• Subjects: Arterial stiffness; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Central blood pressure, Diastolic function; Echocardiography; Health aspects; Heart; Left ventricle; Medical research; Morphology; Risk factors; 내과학
• ISSN: 2056-5909; 1342-2154; 2635-6325; 2056-5909
• DOI: 10.1186/s40885-019-0125-9

This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function. A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day. In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (  > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (  = 0.258,  = 0.025), the significance was lost after controlling for potential confounder (  = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (   0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (  = - 0.258,  = 0.025), but not with E/e´ (  = 0.074). CPP correlated with both septal e´ velocity (  = - 0.300,  = 0.014) and E/e´ (  = 0.428,  = 0.002) in the same multivariable model. In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.