Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island

Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here...

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Published in:Biotechnology and bioprocess engineering 2020, 25(4), , pp.543-550
Main Authors: Min, Seul Ki, Kim, Jung Eun, Hong, Ju-Mi, Yim, Joung Han, Park, Hyun, Youn, Ui Joung, Han, Se Jong, Kim, Il-Chan
Format: Article
Language:English
Subjects:
Biotechnology
Chemistry
Chemistry and Materials Science
Collagen
Cyclooxygenase-2
Damage accumulation
Desalination
Detoxification
Diet
Dietary minerals
Food intake
Hepatocytes
Hepatotoxicity
Industrial and Production Engineering
Inflammation
Liver
Magma
Mineral water
Minerals
NF-κB protein
Nitric oxide
Nitric-oxide synthase
Proteins
Research Paper
Rheumatoid arthritis
Seawater
Silymarin
Thioacetamide
Tumor necrosis factor-TNF
생물공학
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container_issue 4
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container_title Biotechnology and bioprocess engineering
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creator Min, Seul Ki
Kim, Jung Eun
Hong, Ju-Mi
Yim, Joung Han
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Youn, Ui Joung
Han, Se Jong
Kim, Il-Chan
description Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1ß and 1α (IL-6, IL-1ß and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.
doi_str_mv 10.1007/s12257-019-0371-4
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There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1ß and 1α (IL-6, IL-1ß and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. 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source ABI/INFORM Global; Springer Link
subjects Biotechnology
Chemistry
Chemistry and Materials Science
Collagen
Cyclooxygenase-2
Damage accumulation
Desalination
Detoxification
Diet
Dietary minerals
Food intake
Hepatocytes
Hepatotoxicity
Industrial and Production Engineering
Inflammation
Liver
Magma
Mineral water
Minerals
NF-κB protein
Nitric oxide
Nitric-oxide synthase
Proteins
Research Paper
Rheumatoid arthritis
Seawater
Silymarin
Thioacetamide
Tumor necrosis factor-TNF
생물공학
title Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island
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