The platelet-to-lymphocyte ratio as a significant prognostic factor to predict survival outcomes in patients with synchronous metastatic renal cell carcinoma

PURPOSEThe clinical impact of the platelet-to-lymphocyte ratio (PLR) on the prognosis of patients with metastatic renal cell carcinoma (mRCC) remains controversial. We investigated the associations between elevation of the PLR and disease prognosis in patients with synchronous mRCC. MATERIALS AND ME...

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Published in:Investigative and clinical urology 2020, 61(5), , pp.475-481
Main Authors: Yuk, Hyeong Dong, Kang, Minyong, Hwang, Eu Chang, Park, Jae Young, Jeong, Chang Wook, Song, Cheryn, Seo, Seong Il, Byun, Seok-Soo, Kwak, Cheol, Hong, Sung-Hoo, Chung, Jinsoo, Lee, Hakmin
Format: Article
Language:English
Subjects:
biomarkers
blood platelets
kidney neoplasms
lymphocytes
neoplasm metastasis
Original
비뇨기과학
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Summary:PURPOSEThe clinical impact of the platelet-to-lymphocyte ratio (PLR) on the prognosis of patients with metastatic renal cell carcinoma (mRCC) remains controversial. We investigated the associations between elevation of the PLR and disease prognosis in patients with synchronous mRCC. MATERIALS AND METHODSThe data of 1,505 patients with synchronous mRCC were retrospectively analyzed. The entire cohort was stratified into two subgroups according to PLR. Kaplan-Meier and Cox proportional analyses were performed to investigate the possible associations between the PLR and disease prognosis. RESULTSThere were 921 patients with a high PLR and 584 patients with a low PLR by use of the cutoff of 146. The patients with a high PLR had worse clinical characteristics in terms of advanced clinical stage (p
ISSN:2466-0493
2466-054X
DOI:10.4111/icu.20200002