Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation

The inner ear is a complex and delicate structure composed of the cochlea and the vestibular system. To maintain normal auditory function, strict homeostasis of the inner ear is needed. A proper immune response against infection, thus, is crucial. Also, since excessive immune reaction can easily dam...

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Bibliographic Details
Published in:BMB reports 2020, 53(9), , pp.449-452
Main Authors: Rhyu, Hyeong-Jun, Bae, Seong Hoon, Jung, Jinsei, Hyun, Young-Min
Format: Article
Language:English
Subjects:
Invited Mini Review
화학
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Summary:The inner ear is a complex and delicate structure composed of the cochlea and the vestibular system. To maintain normal auditory function, strict homeostasis of the inner ear is needed. A proper immune response against infection, thus, is crucial. Also, since excessive immune reaction can easily damage the normal architecture within the inner ear, the immune response should be fine regulated. The exact mechanism how the inner ear’s immune response, specifically the innate immunity, is regulated was unknown. Recently, we reported a protein selectively localized in the inner ear during bacterial infection, named cochlin, as a possible mediator of such regulation. In this review, the immunological function of cochlin and the mechanism behind its role within inner ear immunity is sum-marized. Cochlin regulates innate immunity by physically en-trapping pathogens within scala tympani and recruiting innate immune cells. Such mechanism enables efficient removal of pathogen while preserving the normal inner ear structure from inflammatory damage.
ISSN:1976-6696
1976-670X
DOI:10.5483/BMBRep.2020.53.9.104