Comparative analysis of acute and chronic stress-induced neurobehavioral alteration and liver injury in mice

Backgrounds Recent research has shown that stress has a significant influence on the functions of many organs. Objective The present study investigated the effect of acute or chronic restraint stress on physiological and psychological processes. Results In the acute stress group, body weight and foo...

Full description

Saved in:
Bibliographic Details
Published in:Molecular & cellular toxicology 2020, 16(4), , pp.367-375
Main Authors: Oh, Tae Woo, Kim, Kwang-Youn, Do, Hyun Ju, Kim, Young-Woo, Park, Kwang-Il
Format: Article
Language:English
Subjects:
Astrocytes
Biomedical and Life Sciences
Body weight
Cell Biology
Comparative analysis
Corticosterone
Cortisol
Food intake
Glial fibrillary acidic protein
Life Sciences
Liver
Original Article
Pharmacology/Toxicology
Serum levels
생물학
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Backgrounds Recent research has shown that stress has a significant influence on the functions of many organs. Objective The present study investigated the effect of acute or chronic restraint stress on physiological and psychological processes. Results In the acute stress group, body weight and food intake did not change, but in the chronic stress group, food intake significantly increased and body weight was significantly inhibited. ALT and AST levels were significantly increased by both groups. Acute and chronic restraint stress led to different behavioral changes. Serum levels of corticosterone and cortisol were more increased in chronic stress than in acute stress. The levels of neurons and astrocyte in the hippocampus, and the NeuN-positive neuronal cells remained unaffected by acute stress, but were decreased by chronic stress. GFAP-positive astrocytes were increased by both groups. Conclusion In summary, our study provides evidence of a relationship between liver injury and behavioral change upon exposure to restraint stress.
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-020-00094-6