Comparison of Fentanyl versus Meperidine in Combination with Midazolam for Sedative Colonoscopy in Korea

BACKGROUND/AIMSCombination of midazolam and opioids is used widely for endoscopic sedation. Compared with meperidine, fentanyl is reportedly associated with rapid recovery, turnover rate of endoscopy room, and quality of endoscopy. We compared fentanyl with meperidine when combined with midazolam fo...

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Bibliographic Details
Published in:Clinical endoscopy 2020, 53(5), , pp.562-567
Main Authors: Hong, Gwan Woo, Lee, Jun Kyu, Lee, Jung Hyeon, Bong, Ji Hun, Choi, Sung Hun, Cho, Hyeki, Nam, Ji Hyung, Jang, Dong Kee, Kang, Hyoun Woo, Kim, Jae Hak, Lim, Yun Jeong, Koh, Moon Soo, Lee, Jin Ho
Format: Article
Language:English
Subjects:
colonoscopy
fentanyl
meperidine
midazolam
Original
sedation
내과학
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Summary:BACKGROUND/AIMSCombination of midazolam and opioids is used widely for endoscopic sedation. Compared with meperidine, fentanyl is reportedly associated with rapid recovery, turnover rate of endoscopy room, and quality of endoscopy. We compared fentanyl with meperidine when combined with midazolam for sedative colonoscopy. METHODSA retrospective, cross-sectional, 1:2 matching study was conducted. Induction and recovery time were compared as the primary outcomes. Moreover, cecal intubation time, withdrawal time, total procedure time of colonoscopy, paradoxical reaction, adenoma detection rate, and adverse effect of midazolam or opioids were assessed as the secondary outcomes. RESULTSA total of 129 subjects (43 fentanyl vs. 86 meperidine) were included in the analysis. The fentanyl group showed significantly more rapid induction time (4.5±2.7 min vs. 7.5±4.7 min, p
ISSN:2234-2400
2234-2443
DOI:10.5946/ce.2020.022