Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective

The glymphatic system hypothesis is a concept describing the clearance of waste products from the brain. The term "glymphatic system" combines the glial and lymphatic systems and is typically described as follows. The perivascular space functions as a conduit that drains cerebrospinal flui...

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Bibliographic Details
Published in:Korean journal of radiology 2020, 21(11), , pp.1199-1209
Main Authors: Taoka, Toshiaki, Naganawa, Shinji
Format: Article
Language:English
Subjects:
20th century
Aquaporins
Cerebrospinal fluid
Cerebrospinal Fluid - physiology
Contrast Media - chemistry
Diffusion Tensor Imaging
Glymphatic System - diagnostic imaging
Glymphatic System - physiology
Humans
Hydrodynamics
Hypotheses
Lymphatic system
Magnetic Resonance Imaging
Microscopy
Nervous system
Nervous System Diseases - diagnostic imaging
Nervous System Diseases - physiopathology
Neuroimaging - methods
Neuroimaging and Head & Neck
Physiology
Veins & arteries
방사선과학
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Summary:The glymphatic system hypothesis is a concept describing the clearance of waste products from the brain. The term "glymphatic system" combines the glial and lymphatic systems and is typically described as follows. The perivascular space functions as a conduit that drains cerebrospinal fluid (CSF) into the brain parenchyma. CSF guided to the perivascular space around the arteries enters the interstitium of brain tissue via aquaporin-4 water channels to clear waste proteins into the perivascular space around the veins before being drained from the brain. In this review, we introduce the glymphatic system hypothesis and its association with fluid dynamics, sleep, and disease. We also discuss imaging methods to evaluate the glymphatic system.
ISSN:1229-6929
2005-8330
DOI:10.3348/kjr.2020.0042