Polymer-Directed Crystallization of Luteolin, Quercetin, and Myricetin

for active pharmaceutical ingredients, the bioavailability, stability, and processability critically depend on crystal habit and size. The presence of polymers in a crystallization solution can engineer broader ranges of crystal habit and size, but only in certain cases. To elucidate the underlying...

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Bibliographic Details
Published in:Macromolecular research 2020, 28(13), , pp.1276-1281
Main Authors: Kim, Hyeongju, Kim, Jeongeun, Kwon, O-Pil, Lee, Jonghwi
Format: Article
Language:English
Subjects:
Bioavailability
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Composite structures
Crystallization
Crystals
Nanochemistry
Nanotechnology
Particulate composites
Physical Chemistry
Polyethylene glycol
Polyethyleneimine
Polymer Sciences
Polymers
Polyphenols
Polyvinyl alcohol
Selectivity
Soft and Granular Matter
고분자공학
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Summary:for active pharmaceutical ingredients, the bioavailability, stability, and processability critically depend on crystal habit and size. The presence of polymers in a crystallization solution can engineer broader ranges of crystal habit and size, but only in certain cases. To elucidate the underlying mechanism of this selectivity, polymer-directed crystallization was systematically investigated here for a series of natural polyphenols, namely luteolin, quercetin, and myricetin. Significant changes in crystal habit and size were observed in the cases of quercetin and myricetin. Peak broadening in X-ray diffraction profiles and significant amounts of polymer within the crystallized particles suggested possible composite structure formation via a non-classical crystallization mechanism. Polyethyleneimine and poly(vinyl alcohol) showed relatively stronger crystal engineering effects than poly(ethylene glycol). The results facilitate understanding of the specific interactions important for crystal engineering and thus preparing polyphenols to attain wide ranges of habit and particle size for various applications.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-020-8163-4