Risk Factors for Mortality in Hospitalized Patients with COVID-19: An Overview in a Mexican Population

• Published in: Tuberculosis and respiratory diseases 2020, 83(0), , pp.46-54
• Main Authors: Cortés-Tellés, Arturo, López-Romero, Stephanie, Mancilla-Ceballos, Roberto, Ortíz-Farías, Diana Lizbeth, Núñez-Caamal, Nelda, Figueroa-Hurtado, Esperanza
• Format: Article
• Language: English
• Subjects: covid-19; hospitalization; intensive care units; mexico; mortality; Original; risk factors; 내과학
• ISSN: 1738-3536; 2005-6184
• DOI: 10.4046/trd.2020.0095

Currently, Mexico ranks third worldwide in mortality due to coronavirus disease pandemic 2019 (COVID-19) and reliable information is scarce, with the available data focused on epidemiological characteristics. This study aimed to identify the risk factors associated with mortality and outcomes in hospitalized Mexican patients with COVID-19. We prospectively assessed patients admitted to a COVID-19 reference center in southeast Mexico between March 28 and June 30, 2020. Mortality was defined as survivors or non-survivors and univariate and multivariate logistic regression analyses were performed to explore the association of the clinical characteristics and laboratory parameters with mortality. We included 200 patients with a mean age of 55 years, 69% were men and 72% had at least one chronic comorbidity. Eighty-six patients required invasive mechanical ventilation (IMV) with an overall mortality rate of 82.5%. Only 51% of the patients with IMV were admitted to the intensive care unit (ICU), with a survival rate of 27.3%, but only 7.2% for patients without ICU admissions (p=0.014). The multivariate analysis found that a neutrophil-to-lymphocyte ratio ≥9 (odds ratio [OR], 4.64; 95% confidence interval [CI], 2.05-10.53) albumin