The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease

• Published in: Tuberculosis and respiratory diseases 2020, 83(0), , pp.25-33
• Main Authors: Kim, Won-Dong, Chi, Hyun-Sook, Choe, Kang-Hyeon, Kim, Woo-Sung, Hogg, James C, Sin, Don D
• Format: Article
• Language: English
• Subjects: cd8 t cell; centrilobular emphysema; chronic obstructive pulmonary disease; granzyme b positive cell; Original; regulatory cells; 내과학
• ISSN: 1738-3536; 2005-6184
• DOI: 10.4046/TRD.2020.0089

Lung inflammation plays a vital role in the pathogenesis of chronic obstructive pulmonary disease (COPD), but the characteristics of the inflammatory process remain unclear. There is growing interest in the role of granzyme B (GzmB) because CD8+ T cells can induce apoptosis of target cells by releasing GzmB, which in turn may cause tissue injury and remodeling. However, GzmB is also expressed by regulatory cells, which are able to suppress CD8+ T cell. The role of GzmB+ cells needs to be defined in COPD. GzmB+ and CD8+ cells on alveolar wall of surgically resected lungs of microscopically classified 12 nonsmoking control, 12 panlobular emphysema (PLE) and 30 centrilobular emphysema (CLE) subjects were localized by immunohistochemical method. Positively stained cells on alveolar wall were counted and length of corresponding alveolar wall was measured. The results were expressed as mean number of positively stained cells per mm of alveolar wall in each subject. The number of GzmB+ and CD8+ cells on alveolar wall of CLE was greater than that of control or PLE subjects (p