Antibreast Cancer Activity of Aspirin-Conjugated Chalcone Polymeric Micelles

Chalcones are hydrophobic polyphenols with poor aqueous solubility. In this study, we prepared a new aspirin-conjugated chalcone derivative-loaded nanoparticle (AS-DK143-loaded NP) using mPEG-PLA co-polymer which, in an aqueous environment, spontaneously forms a micellar formulation with an average...

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Bibliographic Details
Published in:Macromolecular research 2021, 29(1), , pp.105-110
Main Authors: Lee, Do Young, Lee, Kang Pa, Beak, Suji, Park, Ji Su, Kim, Young Jin, Kim, Kil-Nam, Kim, Song-Rae, Yoon, Myeong Sik
Format: Article
Language:English
Subjects:
Anticancer properties
Aqueous environments
Aspirin
Cancer
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Copolymers
Micelles
Nanochemistry
Nanoparticles
Nanotechnology
Physical Chemistry
Polymer Sciences
Polyphenols
Soft and Granular Matter
Toxicity
Tumors
고분자공학
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Summary:Chalcones are hydrophobic polyphenols with poor aqueous solubility. In this study, we prepared a new aspirin-conjugated chalcone derivative-loaded nanoparticle (AS-DK143-loaded NP) using mPEG-PLA co-polymer which, in an aqueous environment, spontaneously forms a micellar formulation with an average particle size of 22.55 nm. Exposure to varying concentrations of AS-DK143 NP significantly diminished the cell viability of 4T1 cells in a concentration-dependent manner. In tumor regression and biodistribution studies in 4T1-luc cell bearing mice, AS-DK143 NPs were shown to selectively target cancer cells and significantly reduce tumor size. These properties suggest anti-cancer efficacy, combined with low toxicity to healthy tissues, indicating a potential role as a safer alternative to currently available chemotherapy agents.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-021-9010-y