Production of Uniform Microspheres Using a Simple Microfluidic Device with Silica Capillary

A microfluidic device is fabricated by using silica capillary with 50 µm inner diameter and 150 µm outer diameter. This device is simple to fabricate by pouring the silica capillary with polydimethylsiloxane (PDMS), then removing the capillary after curing, to form the entire micrometer regime. This...

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Bibliographic Details
Published in:Macromolecular research 2021, 29(1), , pp.82-88
Main Authors: Ahn, Guk Young, Choi, Inseong, Song, Minju, Han, Soo Kyung, Choi, Kangho, Choi, Sung-Wook
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Coefficient of variation
Complex Fluids and Microfluidics
Droplets
Flow velocity
Microfluidic devices
Microspheres
Nanochemistry
Nanoparticles
Nanotechnology
Physical Chemistry
Polydimethylsiloxane
Polyethylene glycol
Polymer Sciences
Silicon dioxide
Soft and Granular Matter
고분자공학
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Summary:A microfluidic device is fabricated by using silica capillary with 50 µm inner diameter and 150 µm outer diameter. This device is simple to fabricate by pouring the silica capillary with polydimethylsiloxane (PDMS), then removing the capillary after curing, to form the entire micrometer regime. This device can easily regulate the size of the oil-in-water (O/W) emulsion droplets by changing the flow rate of the continuous phase. The generated emulsion droplets can be reduced to a size of about 75 µm, and produced in uniform size with a coefficient of variation of 2.6%. The polymeric microbeads using organic solvent were produced by mixing hydrophobic PDMS with PDMS-poly(ethylene glycol) to provide hydrophilicity. In addition, it was confirmed that this device can produce uniform emulsion droplets, even in the changed T-junction form. We believe that the microfluidic device with silica capillary can be used as a potential technique for the encapsulation and delivery of various therapeutic drugs.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-021-9012-9