Chimeric crRNAs Retaining Activity of Cas12a with Potential to Improve Specificity

RNA residues in the guide region of crRNA for Cas12a can be partially replaced by DNA.

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Bibliographic Details
Published in:Bulletin of the Korean Chemical Society 2021, 42(1), , pp.87-90
Main Authors: Park, Jihyun, Choi, Jaewoo, Duong, Men Thi Hoai, Ahn, Hee‐Chul, Hong, Seung Woo, Hwang, Gil Tae, An, Jinsu, Chung, Hak Suk, Ahn, Dae‐Ro
Format: Article
Language:English
Subjects:
Cas12a
Chimeric crRNA
CRISPR‐Cas
화학
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Description
Summary:RNA residues in the guide region of crRNA for Cas12a can be partially replaced by DNA.
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.12109