Capillary leak syndrome and disseminated intravascular coagulation after kidney transplantation in a patient with hereditary angioedema - A case report

Hereditary angioedema (HAE) is a rare disease caused by the deficiency of C1 esterase inhibitor. HAE has a risk of life-threatening complications such as capillary leak syndrome (CLS) and disseminated intravascular coagulation (DIC). A 42-year-old male patient with HAE presented for deceased-donor k...

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Bibliographic Details
Published in:Anesthesia and pain medicine (Korean society of anesthesiologists) 2021, 16(1), , pp.75-80
Main Authors: Park, Jeong Wook, Seo, Jinyoung, Kim, Sang Hun, Jung, Ki Tae
Format: Article
Language:English
Subjects:
capillary leak syndrome
complement c1 inhibitor protein
complement c1s
disseminated intravascular coagulation
hereditary angioedema
kidney transplantation
Transplantation Anesthesia
마취과학
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Summary:Hereditary angioedema (HAE) is a rare disease caused by the deficiency of C1 esterase inhibitor. HAE has a risk of life-threatening complications such as capillary leak syndrome (CLS) and disseminated intravascular coagulation (DIC). A 42-year-old male patient with HAE presented for deceased-donor kidney transplantation. Prophylactic fresh frozen plasma (FFP) was given before surgery because of the risk of edema development. With careful management during anesthesia, there were no problems during surgery. However, generalized edema, hypotension, hypoalbuminemia, massive drainage of serosanguineous fluids from the intraabdominal space, and DIC occurred on the day after surgery. CLS was suspected and sustained hypotension with generalized edema became worse despite treatment with albumin, danazol, FFP, and vasoactive drugs. The patient's condition worsened despite intensive care and he died due to shock. The anesthesiologist should prepare for the critical complications of HAE and prepare the appropriate treatment options.
ISSN:1975-5171
2383-7977
DOI:10.17085/apm.20098