Stunning symmetries involved in the self-assembly of the HSV-1 capsid

Herpes simplex virus-1 (HSV-1) is an enveloped dsDNA virus, infecting ~ 67% of humans. Here, we present the essential components of the HSV-1, focusing on stunning symmetries on the capsid. However, little is known about how the symmetries are involved dynamically in the self-assembly process. We su...

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Bibliographic Details
Published in:Journal of the Korean Physical Society 2021, 78(5), , pp.357-364
Main Authors: Lee, Joo-hyeon, Shim, Jaehyu, Kim, Seung Joong
Format: Article
Language:English
Subjects:
Herpes viruses
Mathematical and Computational Physics
Particle and Nuclear Physics
Physics
Physics and Astronomy
Review
Self-assembly
Small angle X ray scattering
Theoretical
Viruses
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Summary:Herpes simplex virus-1 (HSV-1) is an enveloped dsDNA virus, infecting ~ 67% of humans. Here, we present the essential components of the HSV-1, focusing on stunning symmetries on the capsid. However, little is known about how the symmetries are involved dynamically in the self-assembly process. We suggest small angle X-ray scattering as a suitable method to capture the dynamics of self-assembly. Furthermore, our understanding of the viruses can be expanded by using an integrative approach that combines heterogeneous types of data, thus promoting new diagnostic tools and a cure for viral infections.
ISSN:0374-4884
1976-8524
DOI:10.1007/s40042-020-00044-4