High density lipoprotein mimicking nanoparticles for atherosclerosis

Atherosclerosis is a major contributor to many cardiovascular events, including myocardial infarction, ischemic stroke, and peripheral arterial disease, making it the leading cause of death worldwide. High-density lipoproteins (HDL), also known as “good cholesterol”, have been shown to demonstrate a...

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Bibliographic Details
Published in:Nano convergence 2020, 7(4), , pp.1-14
Main Authors: Chen, Jun, Zhang, Xixi, Millican, Reid, Creutzmann, Jacob Emil, Martin, Sean, Jun, Ho-Wook
Format: Article
Language:English
Subjects:
Atherosclerosis
Chemistry and Materials Science
Cholesterol
Density
Health risk assessment
High-density lipoprotein
Imaging contrast agents
Lipoproteins
Materials Science
Myocardial infarction
Nanoparticles
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Novel Nanotechnology-based Medical Toolkits
Review
Target recognition
Theranostic agents
Therapeutic delivery
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Summary:Atherosclerosis is a major contributor to many cardiovascular events, including myocardial infarction, ischemic stroke, and peripheral arterial disease, making it the leading cause of death worldwide. High-density lipoproteins (HDL), also known as “good cholesterol”, have been shown to demonstrate anti-atherosclerotic efficacy through the removal of cholesterol from foam cells in atherosclerotic plaques. Because of the excellent anti-atherosclerotic properties of HDL, in the past several years, there has been tremendous attention in designing HDL mimicking nanoparticles (NPs) of varying functions to image, target, and treat atherosclerosis. In this review, we are summarizing the recent progress in the development of HDL mimicking NPs and their applications for atherosclerosis.
ISSN:2196-5404
2196-5404
DOI:10.1186/s40580-019-0214-1