Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features

We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2021, 55(3), , pp.225-229
Main Authors: Kim, Dong Ja, Lee, SangHan, Kim, Mee-Seon, Hwang, Jeong-Hyun, Hahm, Myong Hun
Format: Article
Language:English
Subjects:
Case reports
Case Study
Cytoplasm
Hormones
Magnetic resonance imaging
neoplasms
oncocytoma
Patients
Pituitary gland
progression
Radiation therapy
radiology
sella turcica
Surgery
Thyroid gland
Transcription factors
Tumors
병리학
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Summary:We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. In this report, we proposed distinctive radiologic features for differential diagnosis between SCO and other pituitary tumors.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2021.01.27