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Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features
We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After...
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Published in: | Journal of pathology and translational medicine 2021, 55(3), , pp.225-229 |
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description | We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. In this report, we proposed distinctive radiologic features for differential diagnosis between SCO and other pituitary tumors. |
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A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. In this report, we proposed distinctive radiologic features for differential diagnosis between SCO and other pituitary tumors.</description><identifier>ISSN: 2383-7837</identifier><identifier>EISSN: 2383-7845</identifier><identifier>DOI: 10.4132/jptm.2021.01.27</identifier><identifier>PMID: 33677954</identifier><language>eng</language><publisher>Korea (South): Korean Society of Pathologists, Korean Society for Cytopathology</publisher><subject>Case reports ; Case Study ; Cytoplasm ; Hormones ; Magnetic resonance imaging ; neoplasms ; oncocytoma ; Patients ; Pituitary gland ; progression ; Radiation therapy ; radiology ; sella turcica ; Surgery ; Thyroid gland ; Transcription factors ; Tumors ; 병리학</subject><ispartof>Journal of Pathology and Translational Medicine, 2021, 55(3), , pp.225-229</ispartof><rights>2021. This work is published under https://www.jpatholtm.org/articles/archive.php (the “License”). 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Lee, SangHan ; Kim, Mee-Seon ; Hwang, Jeong-Hyun ; Hahm, Myong Hun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-108b8a5394ec4d80a2c784462a282809db8f309dc2a23cab467e0b1c65d7a40b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Case reports</topic><topic>Case Study</topic><topic>Cytoplasm</topic><topic>Hormones</topic><topic>Magnetic resonance imaging</topic><topic>neoplasms</topic><topic>oncocytoma</topic><topic>Patients</topic><topic>Pituitary gland</topic><topic>progression</topic><topic>Radiation therapy</topic><topic>radiology</topic><topic>sella turcica</topic><topic>Surgery</topic><topic>Thyroid gland</topic><topic>Transcription factors</topic><topic>Tumors</topic><topic>병리학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dong Ja</creatorcontrib><creatorcontrib>Lee, SangHan</creatorcontrib><creatorcontrib>Kim, Mee-Seon</creatorcontrib><creatorcontrib>Hwang, Jeong-Hyun</creatorcontrib><creatorcontrib>Hahm, Myong Hun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Journal of pathology and translational medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dong Ja</au><au>Lee, SangHan</au><au>Kim, Mee-Seon</au><au>Hwang, Jeong-Hyun</au><au>Hahm, Myong Hun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features</atitle><jtitle>Journal of pathology and translational medicine</jtitle><addtitle>J Pathol Transl Med</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>55</volume><issue>3</issue><spage>225</spage><epage>229</epage><pages>225-229</pages><issn>2383-7837</issn><eissn>2383-7845</eissn><abstract>We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. 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subjects | Case reports Case Study Cytoplasm Hormones Magnetic resonance imaging neoplasms oncocytoma Patients Pituitary gland progression Radiation therapy radiology sella turcica Surgery Thyroid gland Transcription factors Tumors 병리학 |
title | Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features |
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