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Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis
Background Artemether/lumefantrine (AL), sold under the brand name Coartem, is the most common artemisinin-based combination therapy for the treatment of malaria. Drug-induced oculogyric crisis is a neurological disorder characterized by frequent upward deviations of the eye. In the literature, no c...
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| Published in: | Maxillofacial plastic and reconstructive surgery 2021, 43(0), , pp.1-4 |
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| container_title | Maxillofacial plastic and reconstructive surgery |
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| creator | Amponsah, Emmanuel Kofi Sodnom-Ish, Buyanbileg Anyetei-Anum, Aaron Sowah Frimpong, Paul Kim, Soung Min |
| description | Background
Artemether/lumefantrine (AL), sold under the brand name Coartem, is the most common artemisinin-based combination therapy for the treatment of malaria. Drug-induced oculogyric crisis is a neurological disorder characterized by frequent upward deviations of the eye. In the literature, no cases of Coartem-induced oculogyric crisis have been reported in Ghana.
Case presentation
A 19-year-old male patient, who presented fever measuring 37.9 °C, general body pains, and weakness was prescribed with antimalarial therapy artemether/lumefantrine, Coartem®, from a local pharmacy. Just after initiation of treatment, the patient complained of double vision, involuntary upward eye deviation, and inability to close both eyes. The patient was diagnosed with Coartem-induced oculogyric crisis and was treated with the cessation of the causing agent and intramuscular injection of promethazine hydrochloride.
Conclusions
When a patient exhibits a neurological disorder, such as oculogyric crisis, with normal conscious state and normal vital signs, special attention should be given to obtaining a history of recently administered medications. Clinicians should recognize adverse reactions to drugs based on a thorough patient history and examination. The goal of this report was to present Coartem-induced oculogyric crisis. |
| doi_str_mv | 10.1186/s40902-021-00300-y |
| format | article |
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Artemether/lumefantrine (AL), sold under the brand name Coartem, is the most common artemisinin-based combination therapy for the treatment of malaria. Drug-induced oculogyric crisis is a neurological disorder characterized by frequent upward deviations of the eye. In the literature, no cases of Coartem-induced oculogyric crisis have been reported in Ghana.
Case presentation
A 19-year-old male patient, who presented fever measuring 37.9 °C, general body pains, and weakness was prescribed with antimalarial therapy artemether/lumefantrine, Coartem®, from a local pharmacy. Just after initiation of treatment, the patient complained of double vision, involuntary upward eye deviation, and inability to close both eyes. The patient was diagnosed with Coartem-induced oculogyric crisis and was treated with the cessation of the causing agent and intramuscular injection of promethazine hydrochloride.
Conclusions
When a patient exhibits a neurological disorder, such as oculogyric crisis, with normal conscious state and normal vital signs, special attention should be given to obtaining a history of recently administered medications. Clinicians should recognize adverse reactions to drugs based on a thorough patient history and examination. The goal of this report was to present Coartem-induced oculogyric crisis.</description><identifier>ISSN: 2288-8101</identifier><identifier>ISSN: 2288-8586</identifier><identifier>EISSN: 2288-8586</identifier><identifier>DOI: 10.1186/s40902-021-00300-y</identifier><identifier>PMID: 34013443</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Antimalarial ; Artemether-lumefantrine ; Case Report ; Convulsions & seizures ; Dentistry ; Diagnostic tests ; Drug dosages ; Dystonic reactions ; Fever ; Malaria ; Medicine ; Neurological disorders ; Oculogyric crisis ; Oral and Maxillofacial Surgery ; Pharmacy ; Plastic Surgery ; Rapid diagnostic test ; Reconstructive surgery ; Vital signs ; 치의학</subject><ispartof>Maxillofacial Plastic Reconstructive Surgery, 2021, 43(0), , pp.1-4</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c641t-ad9e23dc828c8fd72578f714e2b194eaeb5663a2360573d067fd5695deba841e3</citedby><cites>FETCH-LOGICAL-c641t-ad9e23dc828c8fd72578f714e2b194eaeb5663a2360573d067fd5695deba841e3</cites><orcidid>0000-0002-8492-2904 ; 0000-0002-1647-2155 ; 0000-0002-6916-0489 ; 0000-0002-0720-3025 ; 0000-0002-4239-1420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134644/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2529006655?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34013443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002724644$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Amponsah, Emmanuel Kofi</creatorcontrib><creatorcontrib>Sodnom-Ish, Buyanbileg</creatorcontrib><creatorcontrib>Anyetei-Anum, Aaron Sowah</creatorcontrib><creatorcontrib>Frimpong, Paul</creatorcontrib><creatorcontrib>Kim, Soung Min</creatorcontrib><title>Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis</title><title>Maxillofacial plastic and reconstructive surgery</title><addtitle>Maxillofac Plast Reconstr Surg</addtitle><addtitle>Maxillofac Plast Reconstr Surg</addtitle><description>Background
Artemether/lumefantrine (AL), sold under the brand name Coartem, is the most common artemisinin-based combination therapy for the treatment of malaria. Drug-induced oculogyric crisis is a neurological disorder characterized by frequent upward deviations of the eye. In the literature, no cases of Coartem-induced oculogyric crisis have been reported in Ghana.
Case presentation
A 19-year-old male patient, who presented fever measuring 37.9 °C, general body pains, and weakness was prescribed with antimalarial therapy artemether/lumefantrine, Coartem®, from a local pharmacy. Just after initiation of treatment, the patient complained of double vision, involuntary upward eye deviation, and inability to close both eyes. The patient was diagnosed with Coartem-induced oculogyric crisis and was treated with the cessation of the causing agent and intramuscular injection of promethazine hydrochloride.
Conclusions
When a patient exhibits a neurological disorder, such as oculogyric crisis, with normal conscious state and normal vital signs, special attention should be given to obtaining a history of recently administered medications. Clinicians should recognize adverse reactions to drugs based on a thorough patient history and examination. The goal of this report was to present Coartem-induced oculogyric crisis.</description><subject>Antimalarial</subject><subject>Artemether-lumefantrine</subject><subject>Case Report</subject><subject>Convulsions & seizures</subject><subject>Dentistry</subject><subject>Diagnostic tests</subject><subject>Drug dosages</subject><subject>Dystonic reactions</subject><subject>Fever</subject><subject>Malaria</subject><subject>Medicine</subject><subject>Neurological disorders</subject><subject>Oculogyric crisis</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Pharmacy</subject><subject>Plastic Surgery</subject><subject>Rapid diagnostic test</subject><subject>Reconstructive surgery</subject><subject>Vital signs</subject><subject>치의학</subject><issn>2288-8101</issn><issn>2288-8586</issn><issn>2288-8586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kktr3DAUhUVpacI0f6CLYugmWbjRy7K8KQxDHwOBQpmuhR7XjiYeK5XswPz7KHaSNl10dYX03XOvDgeh9wR_IkSKy8Rxg2mJKSkxZhiXx1folFIpS1lJ8frpTDA5QWcp7THGhFZ1zdhbdMI4Joxzdop2a3cHMUERQdvRh6EYQ7EJOo5wKM7nAuM1xMt-OkCrhzH6AS4ynaZ-9ENX-KEIdupDd4zeFjb65NM79KbVfYKzx7pCv75-2W2-l1c_vm0366vSCk7GUrsGKHNWUmll6-q8nmxrwoEa0nDQYCohmKZM4KpmDou6dZVoKgdGS06ArdDFojvEVt1Yr4L2c-2Cuolq_XO3VU3d1CQ7tELbhXVB79Vt9Acdj3PDfBFip_Jvve1BOQGGCW5IJQynII3TkjJjWiNE1bCHuZ8XrdvJHMBZyLbo_oXoy5fBX-ed7pTMrovs-wqdPwrE8HuCNKqDTxb6Xg8QpqRoRZuGU8JFRj_-g-7DFIds60xhnHeqMkUXysaQUoT2eRmC1UNe1JIXlfOi5ryoY2768Pc3nlue0pEBtgApPw0dxD-z_yN7D-mHy9Q</recordid><startdate>20210517</startdate><enddate>20210517</enddate><creator>Amponsah, Emmanuel Kofi</creator><creator>Sodnom-Ish, Buyanbileg</creator><creator>Anyetei-Anum, Aaron Sowah</creator><creator>Frimpong, Paul</creator><creator>Kim, Soung Min</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><general>SpringerOpen</general><general>대한악안면성형재건외과학회</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-8492-2904</orcidid><orcidid>https://orcid.org/0000-0002-1647-2155</orcidid><orcidid>https://orcid.org/0000-0002-6916-0489</orcidid><orcidid>https://orcid.org/0000-0002-0720-3025</orcidid><orcidid>https://orcid.org/0000-0002-4239-1420</orcidid></search><sort><creationdate>20210517</creationdate><title>Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis</title><author>Amponsah, Emmanuel Kofi ; Sodnom-Ish, Buyanbileg ; Anyetei-Anum, Aaron Sowah ; Frimpong, Paul ; Kim, Soung Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-ad9e23dc828c8fd72578f714e2b194eaeb5663a2360573d067fd5695deba841e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antimalarial</topic><topic>Artemether-lumefantrine</topic><topic>Case Report</topic><topic>Convulsions & seizures</topic><topic>Dentistry</topic><topic>Diagnostic tests</topic><topic>Drug dosages</topic><topic>Dystonic reactions</topic><topic>Fever</topic><topic>Malaria</topic><topic>Medicine</topic><topic>Neurological disorders</topic><topic>Oculogyric crisis</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Pharmacy</topic><topic>Plastic Surgery</topic><topic>Rapid diagnostic test</topic><topic>Reconstructive surgery</topic><topic>Vital signs</topic><topic>치의학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amponsah, Emmanuel Kofi</creatorcontrib><creatorcontrib>Sodnom-Ish, Buyanbileg</creatorcontrib><creatorcontrib>Anyetei-Anum, Aaron Sowah</creatorcontrib><creatorcontrib>Frimpong, Paul</creatorcontrib><creatorcontrib>Kim, Soung Min</creatorcontrib><collection>Springer_OA刊</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Maxillofacial plastic and reconstructive surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amponsah, Emmanuel Kofi</au><au>Sodnom-Ish, Buyanbileg</au><au>Anyetei-Anum, Aaron Sowah</au><au>Frimpong, Paul</au><au>Kim, Soung Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis</atitle><jtitle>Maxillofacial plastic and reconstructive surgery</jtitle><stitle>Maxillofac Plast Reconstr Surg</stitle><addtitle>Maxillofac Plast Reconstr Surg</addtitle><date>2021-05-17</date><risdate>2021</risdate><volume>43</volume><issue>1</issue><spage>13</spage><epage>13</epage><pages>13-13</pages><artnum>13</artnum><issn>2288-8101</issn><issn>2288-8586</issn><eissn>2288-8586</eissn><abstract>Background
Artemether/lumefantrine (AL), sold under the brand name Coartem, is the most common artemisinin-based combination therapy for the treatment of malaria. Drug-induced oculogyric crisis is a neurological disorder characterized by frequent upward deviations of the eye. In the literature, no cases of Coartem-induced oculogyric crisis have been reported in Ghana.
Case presentation
A 19-year-old male patient, who presented fever measuring 37.9 °C, general body pains, and weakness was prescribed with antimalarial therapy artemether/lumefantrine, Coartem®, from a local pharmacy. Just after initiation of treatment, the patient complained of double vision, involuntary upward eye deviation, and inability to close both eyes. The patient was diagnosed with Coartem-induced oculogyric crisis and was treated with the cessation of the causing agent and intramuscular injection of promethazine hydrochloride.
Conclusions
When a patient exhibits a neurological disorder, such as oculogyric crisis, with normal conscious state and normal vital signs, special attention should be given to obtaining a history of recently administered medications. Clinicians should recognize adverse reactions to drugs based on a thorough patient history and examination. The goal of this report was to present Coartem-induced oculogyric crisis.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34013443</pmid><doi>10.1186/s40902-021-00300-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8492-2904</orcidid><orcidid>https://orcid.org/0000-0002-1647-2155</orcidid><orcidid>https://orcid.org/0000-0002-6916-0489</orcidid><orcidid>https://orcid.org/0000-0002-0720-3025</orcidid><orcidid>https://orcid.org/0000-0002-4239-1420</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antimalarial Artemether-lumefantrine Case Report Convulsions & seizures Dentistry Diagnostic tests Drug dosages Dystonic reactions Fever Malaria Medicine Neurological disorders Oculogyric crisis Oral and Maxillofacial Surgery Pharmacy Plastic Surgery Rapid diagnostic test Reconstructive surgery Vital signs 치의학 |
| title | Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis |
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