Possible clinical implications of prostate capsule thickness and glandular epithelial cell density in benign prostate hyperplasia

The negative correlation between BPH-size and incidence of prostate cancer (PCa) is well-documented in the literature, however the exact mechanism is not well-understood. The present study uses histo-anatomical imaging to study prostate volume in correlation to prostate capsule thickness, and glandu...

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Published in:Investigative and clinical urology 2021, 62(4), , pp.423-429
Main Authors: Holder, Katherine G, Galvan, Bernardo, Knight, Andrew S, Ha, Freedom, Collins, Reagan, Weaver, Preston E, Brandi, Luis, de Riese, Werner T
Format: Article
Language:English
Subjects:
Aged
Atrophy
Epithelial Cells - pathology
Fibrosis
Humans
image processing
Image Processing, Computer-Assisted
Male
Middle Aged
Organ Sparing Treatments
Original
prostate
Prostate - pathology
Prostatectomy
prostatic hyperplasia
Prostatic Hyperplasia - pathology
Prostatic Hyperplasia - surgery
Prostatic Neoplasms - pathology
Retrospective Studies
비뇨기과학
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Summary:The negative correlation between BPH-size and incidence of prostate cancer (PCa) is well-documented in the literature, however the exact mechanism is not well-understood. The present study uses histo-anatomical imaging to study prostate volume in correlation to prostate capsule thickness, and glandular epithelial cell density within the peripheral zone (PZ). Specimens were selected from radical prostatectomies ranging from 20 to 160 mL based on ease of anatomical reconstruction by the slides. A total of 60 patients were selected and underwent quantitative measurements of prostate capsule thickness and glandular epithelial density within the PZ using computer-based imaging software. Pearson's correlation and a stepwise multiple linear regression analysis was conducted to determine the relationship between these measured parameters and the clinical characteristic of these patients. Pearson's correlation analysis revealed a strongly significant, negative correlation between prostate volume and glandular epithelial cell density (r(58)=-0.554, p
ISSN:2466-0493
2466-054X
DOI:10.4111/icu.20200605