Risk Factors for Acute Cholangitis Caused by Enterococcus faecalis and Enterococcus faecium

• Published in: Gut and liver 2021, 15(4), , pp.616-624
• Main Authors: Karasawa, Yuki, Kato, Jun, Kawamura, Satoshi, Kojima, Kentaro, Ohki, Takamasa, Seki, Michiharu, Tagawa, Kazumi, Toda, Nobuo
• Format: Article
• Language: English
• Subjects: anti-microbial agents; cholangitis; enterococcus; Original; sphincterotomy; therapeutics; 내과학
• ISSN: 1976-2283; 2005-1212
• DOI: 10.5009/gnl20214

Acute cholangitis (AC) is a potentially life-threatening bacterial infection, and timely antimicrobial treatment, faster than that achieved with bacterial cultures, is recommended. Although the current guidelines refer to empirical antimicrobial treatment, various kinds of antimicrobial agents have been cited because of insufficient analyses on the spectrum of pathogens in AC. spp. is one of the most frequently isolated Gram-positive bacteria from the bile of patients with AC, but its risk factors have not been extensively studied. This study aimed to analyze the risk factors of AC caused by and . Patients with AC who were hospitalized in a Japanese tertiary center between 2010 and 2015 were retrospectively analyzed. Patients' first AC episodes in the hospital were evaluated. A total of 266 patients with AC were identified. and/or was isolated in 56 (21%) episodes of AC. Prior endoscopic sphincterotomy (EST), the presence of a biliary stent, prior cholecystectomy, and past intensive care unit admission were more frequently observed in AC patients with E. faecalis and/or E. faecium than in those without such bacteria. Prior EST was identified as an independent risk factor for AC caused by and/or in the multivariate analysis. Given the intrinsic resistance of and to antibiotics, clinicians should consider empirical therapy with anti-enterococcal antibiotics for patients with prior EST.