Loading…

Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions

PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the me...

Full description

Saved in:
Bibliographic Details
Published in:Yonsei medical journal 2021, 62(8), , pp.767-775
Main Authors: Ju, Hye-Min, Yu, Sun-Nyoung, Ahn, Yong-Woo, Ok, Soo-Min, Ahn, Soon-Cheol, Jeong, Sung-Hee
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33
cites cdi_FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33
container_end_page 775
container_issue 8
container_start_page 767
container_title Yonsei medical journal
container_volume 62
creator Ju, Hye-Min
Yu, Sun-Nyoung
Ahn, Yong-Woo
Ok, Soo-Min
Ahn, Soon-Cheol
Jeong, Sung-Hee
description PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.
doi_str_mv 10.3349/ymj.2021.62.8.767
format article
fullrecord <record><control><sourceid>proquest_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9846321</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2555112075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</originalsourceid><addsrcrecordid>eNpVkUtvEzEUhS1ERUPhB7DzEhYz-P3YIFURj0hBrdqytjwzNnEzsYvttMq_x00qJFZ3cc_57uMA8AGjnlKmPx929z1BBPeC9KqXQr4CC6yl6Aij8jVYII5px6UW5-BtKfcIEYkReQPOKSNacM4XYFimnN1sa0gRDq4-ORfhT1ftDFcpFmjjBJeHmrYhugJDhHXj4K2dw6OFycPrZnSxFvgU6gZe5WZbh3HjYgoTXLvSqOUdOPN2Lu79S70Av759vVv-6NZX31fLy3U3Moxqp5FUXBHpJecEecEYnqj3ijo9CD5NI8Vk0IyxCbWWUMOArLST1RgL6T2lF-DTiRuzN9sxmGTDsf5OZpvN5c3dymjFBCW4ab-ctA_7Yeemsd3QdjcPOexsPhyd_3di2DTOo1FEKyV5A3x8AeT0Z-9KNbtQRjfPNrq0L4a072JM0FGKT9Ixp1Ky8__GYGSeczQtR_OcoxHEKNNypH8BV4KQHQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2555112075</pqid></control><display><type>article</type><title>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</title><source>PubMed Central</source><creator>Ju, Hye-Min ; Yu, Sun-Nyoung ; Ahn, Yong-Woo ; Ok, Soo-Min ; Ahn, Soon-Cheol ; Jeong, Sung-Hee</creator><creatorcontrib>Ju, Hye-Min ; Yu, Sun-Nyoung ; Ahn, Yong-Woo ; Ok, Soo-Min ; Ahn, Soon-Cheol ; Jeong, Sung-Hee</creatorcontrib><description>PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.</description><identifier>ISSN: 0513-5796</identifier><identifier>EISSN: 1976-2437</identifier><identifier>DOI: 10.3349/ymj.2021.62.8.767</identifier><identifier>PMID: 34296555</identifier><language>eng</language><publisher>Yonsei University College of Medicine</publisher><subject>Original ; 의학일반</subject><ispartof>Yonsei Medical Journal, 2021, 62(8), , pp.767-775</ispartof><rights>Copyright: Yonsei University College of Medicine 2021 2021 Yonsei University College of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</citedby><cites>FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</cites><orcidid>0000-0002-5826-6392 ; 0000-0002-9252-6717 ; 0000-0002-2197-0394 ; 0000-0002-2424-7003 ; 0000-0003-1776-371X ; 0000-0002-6296-4775</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298875/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298875/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002740029$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Hye-Min</creatorcontrib><creatorcontrib>Yu, Sun-Nyoung</creatorcontrib><creatorcontrib>Ahn, Yong-Woo</creatorcontrib><creatorcontrib>Ok, Soo-Min</creatorcontrib><creatorcontrib>Ahn, Soon-Cheol</creatorcontrib><creatorcontrib>Jeong, Sung-Hee</creatorcontrib><title>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</title><title>Yonsei medical journal</title><description>PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.</description><subject>Original</subject><subject>의학일반</subject><issn>0513-5796</issn><issn>1976-2437</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkUtvEzEUhS1ERUPhB7DzEhYz-P3YIFURj0hBrdqytjwzNnEzsYvttMq_x00qJFZ3cc_57uMA8AGjnlKmPx929z1BBPeC9KqXQr4CC6yl6Aij8jVYII5px6UW5-BtKfcIEYkReQPOKSNacM4XYFimnN1sa0gRDq4-ORfhT1ftDFcpFmjjBJeHmrYhugJDhHXj4K2dw6OFycPrZnSxFvgU6gZe5WZbh3HjYgoTXLvSqOUdOPN2Lu79S70Av759vVv-6NZX31fLy3U3Moxqp5FUXBHpJecEecEYnqj3ijo9CD5NI8Vk0IyxCbWWUMOArLST1RgL6T2lF-DTiRuzN9sxmGTDsf5OZpvN5c3dymjFBCW4ab-ctA_7Yeemsd3QdjcPOexsPhyd_3di2DTOo1FEKyV5A3x8AeT0Z-9KNbtQRjfPNrq0L4a072JM0FGKT9Ixp1Ky8__GYGSeczQtR_OcoxHEKNNypH8BV4KQHQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Ju, Hye-Min</creator><creator>Yu, Sun-Nyoung</creator><creator>Ahn, Yong-Woo</creator><creator>Ok, Soo-Min</creator><creator>Ahn, Soon-Cheol</creator><creator>Jeong, Sung-Hee</creator><general>Yonsei University College of Medicine</general><general>연세대학교의과대학</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-5826-6392</orcidid><orcidid>https://orcid.org/0000-0002-9252-6717</orcidid><orcidid>https://orcid.org/0000-0002-2197-0394</orcidid><orcidid>https://orcid.org/0000-0002-2424-7003</orcidid><orcidid>https://orcid.org/0000-0003-1776-371X</orcidid><orcidid>https://orcid.org/0000-0002-6296-4775</orcidid></search><sort><creationdate>20210801</creationdate><title>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</title><author>Ju, Hye-Min ; Yu, Sun-Nyoung ; Ahn, Yong-Woo ; Ok, Soo-Min ; Ahn, Soon-Cheol ; Jeong, Sung-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><topic>의학일반</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Hye-Min</creatorcontrib><creatorcontrib>Yu, Sun-Nyoung</creatorcontrib><creatorcontrib>Ahn, Yong-Woo</creatorcontrib><creatorcontrib>Ok, Soo-Min</creatorcontrib><creatorcontrib>Ahn, Soon-Cheol</creatorcontrib><creatorcontrib>Jeong, Sung-Hee</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Yonsei medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Hye-Min</au><au>Yu, Sun-Nyoung</au><au>Ahn, Yong-Woo</au><au>Ok, Soo-Min</au><au>Ahn, Soon-Cheol</au><au>Jeong, Sung-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</atitle><jtitle>Yonsei medical journal</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>62</volume><issue>8</issue><spage>767</spage><epage>775</epage><pages>767-775</pages><issn>0513-5796</issn><eissn>1976-2437</eissn><abstract>PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.</abstract><pub>Yonsei University College of Medicine</pub><pmid>34296555</pmid><doi>10.3349/ymj.2021.62.8.767</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5826-6392</orcidid><orcidid>https://orcid.org/0000-0002-9252-6717</orcidid><orcidid>https://orcid.org/0000-0002-2197-0394</orcidid><orcidid>https://orcid.org/0000-0002-2424-7003</orcidid><orcidid>https://orcid.org/0000-0003-1776-371X</orcidid><orcidid>https://orcid.org/0000-0002-6296-4775</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0513-5796
ispartof Yonsei Medical Journal, 2021, 62(8), , pp.767-775
issn 0513-5796
1976-2437
language eng
recordid cdi_nrf_kci_oai_kci_go_kr_ARTI_9846321
source PubMed Central
subjects Original
의학일반
title Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T17%3A15%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20Metal%20Ions%20and%20Cytokines%20in%20the%20Saliva%20of%20Patients%20with%20Oral%20Lichenoid%20Lesions&rft.jtitle=Yonsei%20medical%20journal&rft.au=Ju,%20Hye-Min&rft.date=2021-08-01&rft.volume=62&rft.issue=8&rft.spage=767&rft.epage=775&rft.pages=767-775&rft.issn=0513-5796&rft.eissn=1976-2437&rft_id=info:doi/10.3349/ymj.2021.62.8.767&rft_dat=%3Cproquest_nrf_k%3E2555112075%3C/proquest_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2555112075&rft_id=info:pmid/34296555&rfr_iscdi=true