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Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions
PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the me...
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Published in: | Yonsei medical journal 2021, 62(8), , pp.767-775 |
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description | PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL. |
doi_str_mv | 10.3349/ymj.2021.62.8.767 |
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MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.</description><identifier>ISSN: 0513-5796</identifier><identifier>EISSN: 1976-2437</identifier><identifier>DOI: 10.3349/ymj.2021.62.8.767</identifier><identifier>PMID: 34296555</identifier><language>eng</language><publisher>Yonsei University College of Medicine</publisher><subject>Original ; 의학일반</subject><ispartof>Yonsei Medical Journal, 2021, 62(8), , pp.767-775</ispartof><rights>Copyright: Yonsei University College of Medicine 2021 2021 Yonsei University College of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</citedby><cites>FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</cites><orcidid>0000-0002-5826-6392 ; 0000-0002-9252-6717 ; 0000-0002-2197-0394 ; 0000-0002-2424-7003 ; 0000-0003-1776-371X ; 0000-0002-6296-4775</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298875/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298875/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002740029$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Hye-Min</creatorcontrib><creatorcontrib>Yu, Sun-Nyoung</creatorcontrib><creatorcontrib>Ahn, Yong-Woo</creatorcontrib><creatorcontrib>Ok, Soo-Min</creatorcontrib><creatorcontrib>Ahn, Soon-Cheol</creatorcontrib><creatorcontrib>Jeong, Sung-Hee</creatorcontrib><title>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</title><title>Yonsei medical journal</title><description>PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.</description><subject>Original</subject><subject>의학일반</subject><issn>0513-5796</issn><issn>1976-2437</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkUtvEzEUhS1ERUPhB7DzEhYz-P3YIFURj0hBrdqytjwzNnEzsYvttMq_x00qJFZ3cc_57uMA8AGjnlKmPx929z1BBPeC9KqXQr4CC6yl6Aij8jVYII5px6UW5-BtKfcIEYkReQPOKSNacM4XYFimnN1sa0gRDq4-ORfhT1ftDFcpFmjjBJeHmrYhugJDhHXj4K2dw6OFycPrZnSxFvgU6gZe5WZbh3HjYgoTXLvSqOUdOPN2Lu79S70Av759vVv-6NZX31fLy3U3Moxqp5FUXBHpJecEecEYnqj3ijo9CD5NI8Vk0IyxCbWWUMOArLST1RgL6T2lF-DTiRuzN9sxmGTDsf5OZpvN5c3dymjFBCW4ab-ctA_7Yeemsd3QdjcPOexsPhyd_3di2DTOo1FEKyV5A3x8AeT0Z-9KNbtQRjfPNrq0L4a072JM0FGKT9Ixp1Ky8__GYGSeczQtR_OcoxHEKNNypH8BV4KQHQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Ju, Hye-Min</creator><creator>Yu, Sun-Nyoung</creator><creator>Ahn, Yong-Woo</creator><creator>Ok, Soo-Min</creator><creator>Ahn, Soon-Cheol</creator><creator>Jeong, Sung-Hee</creator><general>Yonsei University College of Medicine</general><general>연세대학교의과대학</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ACYCR</scope><orcidid>https://orcid.org/0000-0002-5826-6392</orcidid><orcidid>https://orcid.org/0000-0002-9252-6717</orcidid><orcidid>https://orcid.org/0000-0002-2197-0394</orcidid><orcidid>https://orcid.org/0000-0002-2424-7003</orcidid><orcidid>https://orcid.org/0000-0003-1776-371X</orcidid><orcidid>https://orcid.org/0000-0002-6296-4775</orcidid></search><sort><creationdate>20210801</creationdate><title>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</title><author>Ju, Hye-Min ; Yu, Sun-Nyoung ; Ahn, Yong-Woo ; Ok, Soo-Min ; Ahn, Soon-Cheol ; Jeong, Sung-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-90785827f75520f6441d3ff83e9b65ddc312b9444d044168bb0a7ada91167ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><topic>의학일반</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Hye-Min</creatorcontrib><creatorcontrib>Yu, Sun-Nyoung</creatorcontrib><creatorcontrib>Ahn, Yong-Woo</creatorcontrib><creatorcontrib>Ok, Soo-Min</creatorcontrib><creatorcontrib>Ahn, Soon-Cheol</creatorcontrib><creatorcontrib>Jeong, Sung-Hee</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Korean Citation Index</collection><jtitle>Yonsei medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Hye-Min</au><au>Yu, Sun-Nyoung</au><au>Ahn, Yong-Woo</au><au>Ok, Soo-Min</au><au>Ahn, Soon-Cheol</au><au>Jeong, Sung-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions</atitle><jtitle>Yonsei medical journal</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>62</volume><issue>8</issue><spage>767</spage><epage>775</epage><pages>767-775</pages><issn>0513-5796</issn><eissn>1976-2437</eissn><abstract>PURPOSEWe aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs). MATERIALS AND METHODSSubjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Saliva levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α were detected using an enzyme-linked immunosorbent assay. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLL. RESULTSMean concentrations of IL-6 and IL-8 were statistically higher in OLL patients with OPs. The concentration of Ni was high in OLL groups. The concentrations of Cr, Ni, and Au ions in the saliva were positively correlated with IL-8. REU scores were positively correlated with salivary concentrations of IL-6 and IL-8, as well as with concentrations of Cr, Ni, and Au. CONCLUSIONIncreased concentrations of metal ions, especially Ni, in saliva were positively correlated with IL-8 and showed positive correlations with the severity of OLL.</abstract><pub>Yonsei University College of Medicine</pub><pmid>34296555</pmid><doi>10.3349/ymj.2021.62.8.767</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5826-6392</orcidid><orcidid>https://orcid.org/0000-0002-9252-6717</orcidid><orcidid>https://orcid.org/0000-0002-2197-0394</orcidid><orcidid>https://orcid.org/0000-0002-2424-7003</orcidid><orcidid>https://orcid.org/0000-0003-1776-371X</orcidid><orcidid>https://orcid.org/0000-0002-6296-4775</orcidid><oa>free_for_read</oa></addata></record> |
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title | Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions |
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