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Enhanced bone regeneration using poly(trimethylene carbonate)/vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling agent modified hydroxyapatite nanoparticles

•We have developed a novel PTMC/KHA/VH microsphere scaffolds.•The scaffold can provide drug release and excellent biocompatibility.•Decrease the water absorption and weight loss of the PTMC/HA scaffold.•The scaffold offered a porosity, degradation controllability, mechanical properties.•PTMC/KHA/VH...

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Bibliographic Details
Published in:Journal of industrial and engineering chemistry (Seoul, Korea) 2021, 99(0), , pp.134-144
Main Authors: He, Jian, Hu, Xulin, Xing, Luyao, Chen, Dongliang, Peng, Lijun, Liang, Gaofeng, Xiong, Chengdong, Zhang, Xiangchun, Zhang, Lifang
Format: Article
Language:English
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Summary:•We have developed a novel PTMC/KHA/VH microsphere scaffolds.•The scaffold can provide drug release and excellent biocompatibility.•Decrease the water absorption and weight loss of the PTMC/HA scaffold.•The scaffold offered a porosity, degradation controllability, mechanical properties.•PTMC/KHA/VH scaffold can effectively stimulate bone defect regeneration. Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cell attachment, migration, proliferation, and differentiation. To enhance the drug loading, degradation control, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications, we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs, modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. The fabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties, and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity, 100μm pore size, and 208.2MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12 weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreased inflammation response and promoted bone regeneration, suggesting its use as a bioactive structure in bone tissue engineering.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2021.04.021