Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin in treating diabetic auditory neuropathy in an experimental rat model.Methods. Forty Sprague-Dawley rats were...

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Bibliographic Details
Published in:Clinical and experimental otorhinolaryngology 2021, 14(3), , pp.259-267
Main Authors: Doostkam, Aida, Mirkhani, Hossein, Iravani, Kamyar, Karbalay-Doust, Saied, Zarei, Kazem
Format: Article
Language:English
Subjects:
animal model
auditory brainstem response
diabetic neuropathy
histology
Original
rutin
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Summary:Objectives. Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin in treating diabetic auditory neuropathy in an experimental rat model.Methods. Forty Sprague-Dawley rats were randomly assigned to the following groups: group 1, control; group 2, diabetic rats; and groups 3–5, rats treated with rutin (at doses of 50, 100, and 150 mg/kg, respectively). We used auditory brain stem response, stereology of the spiral ganglion, and measurements of superoxide dismutase (SOD) and malondialdehyde (MDA) to evaluate the effects of treatment.Results. Significant improvements in auditory neuropathy were observed in the rutin-treated groups in comparison with the diabetic group (P
ISSN:1976-8710
2005-0720
DOI:10.21053/ceo.2019.02068