Dietary phytochemicals as a promising nutritional strategy for sarcopenia: a systematic review and meta-analysis of randomized controlled trials

The decline in skeletal muscle mass and strength, also called sarcopenia, accelerates with age, leading to negative health outcomes and poor quality of life. Diet is important to promote health and plays a key role in muscle aging. Plant-based foods have recently received attention as sources of phy...

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Bibliographic Details
Published in:Applied biological chemistry 2021, 64(0), , pp.1-14
Main Authors: Jeong, Hye Yun, Kwon, Oran
Format: Article
Language:English
Subjects:
Adults
Aging
Applied Microbiology
Bias
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Clinical trials
Confidence intervals
Diet
Food plants
Health promotion
Meta-analysis
Muscle strength
Older people
Phytochemicals
Plant-based foods
Quality assessment
Quality of life
Reviews
Sarcopenia
Skeletal muscle
Statistical analysis
Systematic review
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Summary:The decline in skeletal muscle mass and strength, also called sarcopenia, accelerates with age, leading to negative health outcomes and poor quality of life. Diet is important to promote health and plays a key role in muscle aging. Plant-based foods have recently received attention as sources of phytochemical components to attenuate loss of muscle mass and strength in older adults. This systematic review and meta-analysis evaluated the benefits of botanical extracts and their phytochemical compounds for muscle health in older adults. Randomized controlled trials were identified via systematic searches of four electronic databases (PubMed, Cochrane Library, Web of Science, and KoreaMed) up to June 2021 and were quality assessed. The results of muscle strength, mass, and physical performance were pooled using a random-effects model. Fourteen studies involving 528 subjects aged between 50 and 80 years met the inclusion criteria. Dietary phytochemicals significantly increased handgrip strength [0.90 kg; 95% confidence interval (CI) 0.26–1.53, p  =  0.01] and physical performance (timed up-and-go test: − 0.5 s, 2.73 times; 95% CI − 0.84 to − 0.15, p  
ISSN:2468-0834
2468-0842
DOI:10.1186/s13765-021-00633-2