Proto-oncogene Pokemon in thyroid cancer: a potential promoter of tumorigenesis in papillary thyroid carcinoma

Background: Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was...

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Bibliographic Details
Published in:Journal of pathology and translational medicine 2021, 55(5), , pp.317-323
Main Authors: Chang, Kyungseek, Do, Sung-Im, Kim, Kyungeun, Chae, Seoung Wan, Do, In-gu, Lee, Hyun Joo, Kim, Dong Hoon, Sohn, Jin Hee
Format: Article
Language:English
Subjects:
Kinases
Lymphatic system
Medical prognosis
Metastasis
Mutation
Original
papillary thyroid carcinoma
pokemon
Proteins
Statistical analysis
Thyroid cancer
Thyroid diseases
thyroid neoplasms
Tumorigenesis
Tumors
zbtb7a
병리학
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Summary:Background: Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.Methods: Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.Results: Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal group, 44.0% from the group with benign thyroid diseases, and 92.1% from the group with PTC (p < .001). The intensity of Pokemon expression was markedly higher in the PTC group. Pokemon expression level and PTC tumor size showed an inverse correlation. T1a tumors showed strong expression levels of Pokemon. However, larger tumors showed weak expression (p = .006).Conclusions: Pokemon expression is associated with tumorigenesis of PTC, with expression showing an inverse correlation with PTC tumor size. This might be related to the negative regulation of aerobic glycolysis by Pokemon.
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2021.06.28