Protective Effects of Titanium Dioxide-based Emulsion after Short-term and Long-term Infrared-A Ray Irradiation on Skin Cells

To accurately evaluate the protective effects of titanium dioxide-based emulsion from infrared-A rays (IRA) irradiation in daily life, we assessed the harmful effects of natural level of IRA irradiation on human skin cells. Using a well-defined solar IRA simulator, short-term (less than seven days)...

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Bibliographic Details
Published in:Biotechnology and bioprocess engineering 2021, 26(4), , pp.595-605
Main Authors: Kim, Jun Yeong, Kim, Su Ji, You, Gayeon, Choi, Eun Seo, Lee, Joo Hang, Mok, Hyejung, Lee, Jun Bae
Format: Article
Language:English
Subjects:
Biotechnology
Cell growth
Cell proliferation
Chemistry
Chemistry and Materials Science
Collagen
Collagen (type I)
Emulsions
Exposure
Fibroblasts
Heat stress
Heat tolerance
I.R. radiation
Industrial and Production Engineering
Irradiation
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
Mimicry
mRNA
Procollagen
Radiation damage
Research Paper
Titanium
Titanium dioxide
생물공학
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Summary:To accurately evaluate the protective effects of titanium dioxide-based emulsion from infrared-A rays (IRA) irradiation in daily life, we assessed the harmful effects of natural level of IRA irradiation on human skin cells. Using a well-defined solar IRA simulator, short-term (less than seven days) IRA irradiation on fibroblasts at 34°C elicited an increase in the matrix metalloproteinase-1 (MMP1) mRNA level and decrease in the collagen type-1 α-1 (COL1A1) mRNA level. While short-term IRA exposure showed negligible effects on cell proliferation at 34°C, long-term (24 days) IRA irradiation significantly decreased the proliferation of fibroblasts at the same temperature. However, in the presence of heat stress at 43°C, short-term IRA exposure also elicited severe damage including reduction in cell proliferation and procollagen type 1 C-terminal peptide (PIP) level. In addition, formulated titanium dioxide-based emulsion (IRA protective cream; IRC) with an infrared-A protection factor value of ten could successfully protect cells from damage by short-term and long-term IRA exposures. In this study, we demonstrated that IRC reduces mild and severe damages elicited by natural level of IRA irradiation mimicking system after short-term and long-term exposures.
ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-020-0308-y