Recent advances in transdermal drug delivery systems: a review

Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and...

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Bibliographic Details
Published in:Biomaterials research 2021, 25(3), , pp.243-257
Main Authors: Jeong, Woo Yeup, Kwon, Mina, Choi, Hye Eun, Kim, Ki Su
Format: Article
Language:English
Subjects:
Ablation
Active/passive method
Characterization
Cosmetics
Cosmetics industry
Drug delivery
Drug delivery systems
Drugs
Methods
Molecular weight
Pain
Patient compliance
Permeability
Physicochemical properties
Review
Skin
Skin care products
Transdermal drug delivery
Transdermal medication
Ultrasonic imaging
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Summary:Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. TDDS could be applicable in not only pharmaceuticals but also in the skin care industry, including cosmetics. Because this method mainly involves local administration, it can prevent local buildup in drug concentration and nonspecific delivery to tissues not targeted by the drug. However, the physicochemical properties of the skin translate to multiple obstacles and restrictions in transdermal delivery, with numerous investigations conducted to overcome these bottlenecks. In this review, we describe the different types of available TDDS methods, along with a critical discussion of the specific advantages and disadvantages, characterization methods, and potential of each method. Progress in research on these alternative methods has established the high efficiency inherent to TDDS, which is expected to find applications in a wide range of fields.
ISSN:2055-7124
1226-4601
2055-7124
DOI:10.1186/s40824-021-00226-6