Hyperuricemia is a risk factor for the progression to end-stage renal disease in minimal change disease

• Published in: Kidney research and clinical practice 2021, 40(3), , pp.411-418
• Main Authors: Song, Su Hyun, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Ryu, Dong Ryeol, Kim, Sung Gyun, Park, Sun-Hee, Ma, Seong Kwon, Kim, Soo Wan, Bae, Eun Hui
• Format: Article
• Language: English
• Subjects: chronic kidney disease; end-stage renal disease; hyperuricemia; minimal change disease; Original; 내과학
• ISSN: 2211-9132; 2211-9140
• DOI: 10.23876/j.krcp.20.220

BACKGROUNDMinimal change disease (MCD) is one of the most common causes of nephrotic syndrome worldwide. Hyperuricemia increases the end-stage renal disease (ESRD) risk in glomerulonephritis. In this study, we aimed to determine the effect of high serum uric acid levels on the progression to ESRD in MCD. METHODSA total of 800 patients diagnosed with MCD by kidney biopsy were retrospectively analyzed. We determined the relationship of hyperuricemia with the progression to ESRD in MCD using the Cox proportional hazard model and Kaplan-Meier survival analysis. The primary outcome was defined as the initiation of dialysis or kidney transplantation. RESULTSA total of 42 patients (5.3%) progressed to ESRD during the follow-up period. In the restricted cubic spline curve, serum uric acid levels exhibited a positive correlation with ESRD progression in patients with MCD. In the fully adjusted model, the risk of MCD progression increased by 29% for every 1 mg/dL increase in the baseline serum uric acid level (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.09-1.54; p = 0.004). Falling into the high uric acid group (serum uric acid level > 7 mg/dL in men and > 6 mg/dL in women) was also a risk factor for progression of MCD to ESRD (HR, 3.40; 95% CI, 1.59-7.31; p < 0.001). CONCLUSIONOur study shows that hyperuricemia is an independent risk factor for the progression to ESRD in patients with MCD.