Loading…
Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats
Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown. Effects of the SMS extract in wa...
Saved in:
| Published in: | Journal of ginseng research 2021, 45(5), , pp.565-574 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3 |
| container_end_page | 574 |
| container_issue | 5 |
| container_start_page | 565 |
| container_title | Journal of ginseng research |
| container_volume | 45 |
| creator | Sung, Yoon-Young Yuk, Heung Joo Kim, Dong-Seon |
| description | Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown.
Effects of the SMS extract in water (SMS-W) and 30% ethanol (SMS-E) were studied in a rat model of potassium oxonate-induced hyperuricemia. Uric acid concentrations and xanthine oxidase (XO) activities were evaluated in the serum, urine, and hepatic tissue. Using renal histopathology to assess kidney function and uric acid excretion, we investigated serum creatinine and blood urea nitrogen concentrations, as well as protein levels of renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), and organic anion transporter 1 (OAT1). The effects of SMS on in vitro XO activity and uric acid uptake were also evaluated. The components of SMS were identified using Ultra Performance Liquid Chromatography (UPLC).
SMS-E reduced serum uric acid and creatinine concentrations, and elevated urine uric acid excretion. SMS-E lowered XO activities in both the serum and liver, and downregulated the expression of renal URAT1 and GLUT9 proteins. SMS-E reduced renal inflammation and IL-1β levels in both the serum and kidneys. SMS-E inhibited both in vitro XO activity and urate uptake in URAT1-expressing oocytes. Using UPLC, 25 ginsenosides were identified, all of which were present in higher levels in SMS-E than in SMS-W.
SMS-E exhibited antihyperuricemic effects by regulating XO activity and renal urate transporters, providing the first evidence of its applicability in the treatment of hyperuricemia and gout.
[Display omitted] |
| doi_str_mv | 10.1016/j.jgr.2021.01.001 |
| format | article |
| fullrecord | <record><control><sourceid>nurimedia_nrf_k</sourceid><recordid>TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9895305</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><nurid>NODE10613969</nurid><els_id>S1226845321000026</els_id><doaj_id>oai_doaj_org_article_9d5219e6dc6a43be9422577bbf16ee88</doaj_id><sourcerecordid>NODE10613969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3</originalsourceid><addsrcrecordid>eNp9klGLEzEQxxdRvPP0A_gieREUbE2ym-wGQTjOUw8OT7TvYTaZbdPuJjXZHu3n8guatufhvQiBgcnv_59hZoriJaNTRpl8v5wu53HKKWdTmh9lj4pTTlU5qVRVPy5OGedy0lSiPCmepbSkVNa8rp4WJ2XV0LLi8rT4_RPQzwfAVQL_jgAZI1g3uuChJwuMbQ5diMOmh32SmOCTS6PzcxI68h08bMnc-ZRNsnrA3oUIIyay2K0xbqIzODgg7Y44v3CtOyi34MeF80jC1llISMCM7taNOwLeEvQL8GbPbfZWBLcm4qG48yRn0vPiSQd9whd38ayYfb6cXXydXN98ubo4v54Y0bBxYpHRFjrLLe0qS0tuFBO2M1wiE1QqKCsrmADZobC1Qd7UXJZ118oaGmzLs-Lt0dbHTq-M0wHcIc6DXkV9_mN2pVWjRElFZq-OrA2w1OvoBoi7g-CQCHGuIY7O9KiVFZwplNZIqMoWVcW5qOu27ZhEbJrs9fHotd60A1qDPu-kf2D68Me7Re7pVjeiqauGZ4M3dwYx_NpgGvXgksG-B49hkzSXlDZcKLXvmx1RE0NKEbv7Mozq_Y3ppc43pvc3pml-lGXNq3_7u1f8PaoMvL4bXN5_JhzcM99uPl0yKlmppMrchyOHeYm3DqNOxqE3WRHRjHl07j9t_AHdVPRl</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2600825995</pqid></control><display><type>article</type><title>Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats</title><source>PubMed Central Free</source><source>Elsevier ScienceDirect Journals</source><creator>Sung, Yoon-Young ; Yuk, Heung Joo ; Kim, Dong-Seon</creator><creatorcontrib>Sung, Yoon-Young ; Yuk, Heung Joo ; Kim, Dong-Seon</creatorcontrib><description>Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown.
Effects of the SMS extract in water (SMS-W) and 30% ethanol (SMS-E) were studied in a rat model of potassium oxonate-induced hyperuricemia. Uric acid concentrations and xanthine oxidase (XO) activities were evaluated in the serum, urine, and hepatic tissue. Using renal histopathology to assess kidney function and uric acid excretion, we investigated serum creatinine and blood urea nitrogen concentrations, as well as protein levels of renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), and organic anion transporter 1 (OAT1). The effects of SMS on in vitro XO activity and uric acid uptake were also evaluated. The components of SMS were identified using Ultra Performance Liquid Chromatography (UPLC).
SMS-E reduced serum uric acid and creatinine concentrations, and elevated urine uric acid excretion. SMS-E lowered XO activities in both the serum and liver, and downregulated the expression of renal URAT1 and GLUT9 proteins. SMS-E reduced renal inflammation and IL-1β levels in both the serum and kidneys. SMS-E inhibited both in vitro XO activity and urate uptake in URAT1-expressing oocytes. Using UPLC, 25 ginsenosides were identified, all of which were present in higher levels in SMS-E than in SMS-W.
SMS-E exhibited antihyperuricemic effects by regulating XO activity and renal urate transporters, providing the first evidence of its applicability in the treatment of hyperuricemia and gout.
[Display omitted]</description><identifier>ISSN: 1226-8453</identifier><identifier>EISSN: 2093-4947</identifier><identifier>DOI: 10.1016/j.jgr.2021.01.001</identifier><identifier>PMID: 34803426</identifier><language>eng</language><publisher>Korea (South): Elsevier B.V</publisher><subject>Hyperuricemia ; Saengmaeksan ; Urate transporter 1 ; Uric acid excretion ; Xanthine oxidase ; 기타의약학</subject><ispartof>Journal of Ginseng Research, 2021, 45(5), , pp.565-574</ispartof><rights>2021</rights><rights>2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V.</rights><rights>2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3</citedby><cites>FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587482/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1226845321000026$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34803426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002785095$$DAccess content in National Research Foundation of Korea (NRF)$$Hfree_for_read</backlink></links><search><creatorcontrib>Sung, Yoon-Young</creatorcontrib><creatorcontrib>Yuk, Heung Joo</creatorcontrib><creatorcontrib>Kim, Dong-Seon</creatorcontrib><title>Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats</title><title>Journal of ginseng research</title><addtitle>J Ginseng Res</addtitle><description>Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown.
Effects of the SMS extract in water (SMS-W) and 30% ethanol (SMS-E) were studied in a rat model of potassium oxonate-induced hyperuricemia. Uric acid concentrations and xanthine oxidase (XO) activities were evaluated in the serum, urine, and hepatic tissue. Using renal histopathology to assess kidney function and uric acid excretion, we investigated serum creatinine and blood urea nitrogen concentrations, as well as protein levels of renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), and organic anion transporter 1 (OAT1). The effects of SMS on in vitro XO activity and uric acid uptake were also evaluated. The components of SMS were identified using Ultra Performance Liquid Chromatography (UPLC).
SMS-E reduced serum uric acid and creatinine concentrations, and elevated urine uric acid excretion. SMS-E lowered XO activities in both the serum and liver, and downregulated the expression of renal URAT1 and GLUT9 proteins. SMS-E reduced renal inflammation and IL-1β levels in both the serum and kidneys. SMS-E inhibited both in vitro XO activity and urate uptake in URAT1-expressing oocytes. Using UPLC, 25 ginsenosides were identified, all of which were present in higher levels in SMS-E than in SMS-W.
SMS-E exhibited antihyperuricemic effects by regulating XO activity and renal urate transporters, providing the first evidence of its applicability in the treatment of hyperuricemia and gout.
[Display omitted]</description><subject>Hyperuricemia</subject><subject>Saengmaeksan</subject><subject>Urate transporter 1</subject><subject>Uric acid excretion</subject><subject>Xanthine oxidase</subject><subject>기타의약학</subject><issn>1226-8453</issn><issn>2093-4947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9klGLEzEQxxdRvPP0A_gieREUbE2ym-wGQTjOUw8OT7TvYTaZbdPuJjXZHu3n8guatufhvQiBgcnv_59hZoriJaNTRpl8v5wu53HKKWdTmh9lj4pTTlU5qVRVPy5OGedy0lSiPCmepbSkVNa8rp4WJ2XV0LLi8rT4_RPQzwfAVQL_jgAZI1g3uuChJwuMbQ5diMOmh32SmOCTS6PzcxI68h08bMnc-ZRNsnrA3oUIIyay2K0xbqIzODgg7Y44v3CtOyi34MeF80jC1llISMCM7taNOwLeEvQL8GbPbfZWBLcm4qG48yRn0vPiSQd9whd38ayYfb6cXXydXN98ubo4v54Y0bBxYpHRFjrLLe0qS0tuFBO2M1wiE1QqKCsrmADZobC1Qd7UXJZ118oaGmzLs-Lt0dbHTq-M0wHcIc6DXkV9_mN2pVWjRElFZq-OrA2w1OvoBoi7g-CQCHGuIY7O9KiVFZwplNZIqMoWVcW5qOu27ZhEbJrs9fHotd60A1qDPu-kf2D68Me7Re7pVjeiqauGZ4M3dwYx_NpgGvXgksG-B49hkzSXlDZcKLXvmx1RE0NKEbv7Mozq_Y3ppc43pvc3pml-lGXNq3_7u1f8PaoMvL4bXN5_JhzcM99uPl0yKlmppMrchyOHeYm3DqNOxqE3WRHRjHl07j9t_AHdVPRl</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Sung, Yoon-Young</creator><creator>Yuk, Heung Joo</creator><creator>Kim, Dong-Seon</creator><general>Elsevier B.V</general><general>고려인삼학회</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>DBRKI</scope><scope>TDB</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>ACYCR</scope></search><sort><creationdate>20210901</creationdate><title>Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats</title><author>Sung, Yoon-Young ; Yuk, Heung Joo ; Kim, Dong-Seon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Hyperuricemia</topic><topic>Saengmaeksan</topic><topic>Urate transporter 1</topic><topic>Uric acid excretion</topic><topic>Xanthine oxidase</topic><topic>기타의약학</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Yoon-Young</creatorcontrib><creatorcontrib>Yuk, Heung Joo</creatorcontrib><creatorcontrib>Kim, Dong-Seon</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>DBPIA - 디비피아</collection><collection>Nurimedia DBPIA Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><collection>Korean Citation Index</collection><jtitle>Journal of ginseng research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Yoon-Young</au><au>Yuk, Heung Joo</au><au>Kim, Dong-Seon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats</atitle><jtitle>Journal of ginseng research</jtitle><addtitle>J Ginseng Res</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>45</volume><issue>5</issue><spage>565</spage><epage>574</epage><pages>565-574</pages><issn>1226-8453</issn><eissn>2093-4947</eissn><abstract>Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown.
Effects of the SMS extract in water (SMS-W) and 30% ethanol (SMS-E) were studied in a rat model of potassium oxonate-induced hyperuricemia. Uric acid concentrations and xanthine oxidase (XO) activities were evaluated in the serum, urine, and hepatic tissue. Using renal histopathology to assess kidney function and uric acid excretion, we investigated serum creatinine and blood urea nitrogen concentrations, as well as protein levels of renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), and organic anion transporter 1 (OAT1). The effects of SMS on in vitro XO activity and uric acid uptake were also evaluated. The components of SMS were identified using Ultra Performance Liquid Chromatography (UPLC).
SMS-E reduced serum uric acid and creatinine concentrations, and elevated urine uric acid excretion. SMS-E lowered XO activities in both the serum and liver, and downregulated the expression of renal URAT1 and GLUT9 proteins. SMS-E reduced renal inflammation and IL-1β levels in both the serum and kidneys. SMS-E inhibited both in vitro XO activity and urate uptake in URAT1-expressing oocytes. Using UPLC, 25 ginsenosides were identified, all of which were present in higher levels in SMS-E than in SMS-W.
SMS-E exhibited antihyperuricemic effects by regulating XO activity and renal urate transporters, providing the first evidence of its applicability in the treatment of hyperuricemia and gout.
[Display omitted]</abstract><cop>Korea (South)</cop><pub>Elsevier B.V</pub><pmid>34803426</pmid><doi>10.1016/j.jgr.2021.01.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1226-8453 |
| ispartof | Journal of Ginseng Research, 2021, 45(5), , pp.565-574 |
| issn | 1226-8453 2093-4947 |
| language | eng |
| recordid | cdi_nrf_kci_oai_kci_go_kr_ARTI_9895305 |
| source | PubMed Central Free; Elsevier ScienceDirect Journals |
| subjects | Hyperuricemia Saengmaeksan Urate transporter 1 Uric acid excretion Xanthine oxidase 기타의약학 |
| title | Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T20%3A27%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nurimedia_nrf_k&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Saengmaeksan,%20a%20traditional%20herbal%20formulation%20consisting%20of%20Panax%20ginseng,%20ameliorates%20hyperuricemia%20by%20inhibiting%20xanthine%20oxidase%20activity%20and%20enhancing%20urate%20excretion%20in%20rats&rft.jtitle=Journal%20of%20ginseng%20research&rft.au=Sung,%20Yoon-Young&rft.date=2021-09-01&rft.volume=45&rft.issue=5&rft.spage=565&rft.epage=574&rft.pages=565-574&rft.issn=1226-8453&rft.eissn=2093-4947&rft_id=info:doi/10.1016/j.jgr.2021.01.001&rft_dat=%3Cnurimedia_nrf_k%3ENODE10613969%3C/nurimedia_nrf_k%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c581t-de10bafd2d0f4d032c915dfc26e15069a34d515a6fe5d7ce2872637fb67a8eb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2600825995&rft_id=info:pmid/34803426&rft_nurid=NODE10613969&rfr_iscdi=true |