Effects of Lactobacillus curvatus MG5246 on inflammatory markers in Porphyromonas gingivalis lipopolysaccharide-sensitized human gingival fibroblasts and periodontitis rat model

This study investigated the effects of Lactobacillus curvatus MG5246 on periodontitis inflammation. Cell-free supernatants (CFS) prepared from L. curvatus MG5246 decreased prostaglandin E2 production and cyclooxygenase-2 gene expression by 60% and 78% in Porphyromonas gingivalis -lipopolysaccharide...

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Published in:Food science and biotechnology 2022, 31(1), , pp.111-120
Main Authors: Jung, Jae-In, Kim, Yong Gyeong, Kang, Chang-Ho, Imm, Jee-Young
Format: Article
Language:English
Subjects:
Alveolar bone
Antibiotic resistance
Antibiotics
Biomedical materials
Bone loss
Chemistry
Chemistry and Materials Science
Chemokines
Cyclooxygenase-2
Fibroblasts
Food Science
Gene expression
Gingiva
Inflammation
Interleukin 6
Lactobacillus curvatus
Lipopolysaccharides
Matrix metalloproteinase
Matrix metalloproteinases
Nutrition
Osteoprotegerin
Periodontitis
Physical growth
Porphyromonas gingivalis
Probiotics
Prostaglandin E2
Research Article
Tumor necrosis factor-α
식품과학
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Summary:This study investigated the effects of Lactobacillus curvatus MG5246 on periodontitis inflammation. Cell-free supernatants (CFS) prepared from L. curvatus MG5246 decreased prostaglandin E2 production and cyclooxygenase-2 gene expression by 60% and 78% in Porphyromonas gingivalis -lipopolysaccharide stimulated human gingival fibroblasts at 400 μg/mL. Gene expressions of tumor necrosis factor-α, interleukin-6, matrix metalloproteinases, and chemokines were significantly downregulated by CFS treatment ( p  
ISSN:1226-7708
2092-6456
2092-6456
DOI:10.1007/s10068-021-01009-4